SPRINT Mind Study Preliminary Data

drawing of a sphygmomanometer connected to heart and brain

CBHI Investigators from Case Western Reserve University School of Medicine and University Hospitals are major contributors to the SPRINT MIND study, funded by the National Institutes of Health. The study  has released preliminary data that seem to indicate that reduction of systolic blood pressure to a target 120 mm Hg (versus 130 mm Hg) may significantly reduce the risk of Mild Cognitive Impairment (MCI), and MCI and dementia (through all causes) combined. While the data are preliminary and have not yet been published, "this is the first randomized clinical trial to demonstrate a reduction in MCI alone, and the combined risk of MCI and all-cause dementia," according to Jeff D. Williamson, MD, MHS, Professor of Internal Medicine and Epidemiology and Chief, Section on Gerontology and Geriatric Medicine at Wake Forest School of Medicine.

Professors at CWRU and UH who participated in the study have also spearheaded the Targeted Management Intervention (TEAM) focused at reducing stroke risk in males of African-American descent. "Our TEAM study has developed an effective behavioral intervention that can help people, especially African-Americans at high risk for stroke, get their blood pressures closer to what we know now are appropriate targets," said Martha Sajatovic MD, Director of the Neurological and Behavioral Outcomes Center at CWRU School of Medicine, and a Professor of Psychiatry at UH, who was first author of the study that appeared in the American Journal of Health Promotion.