Main et. al

Protective genetic variants in the mid-western Amish 

Leighanne R Main1, Michelle C Disher1, Yeunjoo Song1, Renee Laux1, Kristy Miskimen1, Michael L Cuccaro2,3, Paula Ogrocki4, Alan J Lerner1,4, Jeffery M. Vance2,3, M Denise Fuzzell1, Sarada Fuzzell1, Jane Sewell1, Laura J Caywood2, Michael Prough3, Bill Scott2,  Larry D. Adams2, Jason E. Clouse2, Sharlene D. Herington2, Margaret A. Pericak-Vance3,5 and Jonathan L. Haines1 

1Case Western Reserve University School of Medicine, Cleveland, OH, USA
2University of Miami, Miami, FL, USA
3John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA
4University Hospitals Cleveland Medical Center, Cleveland, OH, USA
5The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA

Alzheimer’s disease (AD) increasing in frequency with the aging population. Our goal is to identify protective genetic variants that slow down or stop the progression of AD. We are applying a family-based approach by studying the Amish, an isolated and homogeneous population. By examining genetic variants in the Amish, we hope to gain a deeper understanding of the development of AD and possible novel therapeutic targets.