Lan Zhou, MD, PhD

Associate Professor
Department of Pathology
School of Medicine
Member
GI Cancer Genetics Program
Case Comprehensive Cancer Center

Dr. Lan Zhou earned her MD from Shanghai Medical University in 1991. Dr. Zhou then received her PhD in Molecular and Cell Biology from State University of New York at Buffalo, NY. While a graduate student, she studied gap junction protein regulation by Src oncogene. She then joined the lab of Dr. John Lowe for postdoctoral training in the Howard Hughes Medical Institute, University of Michigan, where she worked on Notch fucosylation modification in hematopoiesis. She completed her Clinical Pathology Residency training followed by Transfusion Medicine Fellowship training at University of Michigan Hospitals. In 2005, Dr. Zhou joined Case Western Research University School of Medicine in the Department of Pathology as an Assistant Professor. She became the Director of the Molecular Diagnostic Laboratory at University Hospitals Cleveland Medical Center in 2007. She is currently an Associate Professor with tenure. Dr. Zhou is board certified in American Board of Clinical Pathology/Transfusion Medicine and American Board of Molecular Genetic Pathology.

Research Information

Research Interests

The research in Dr. Zhou’s laboratory focuses on Notch in hematopoiesis and in cancer biology.

Dr. Zhou’s long term research goals include:

  1. Define the mechanism(s) of which Notch2 regulates hematopoietic stem cell (HSC) quiescence, niche retention and egress
  2. Develop a Notch- ligand targeting strategy to facilitate HSC mobilization and to improve HSC activity in hematopoietic cell therapy
  3. Define the significance of fucosylglycans in the pathogenesis of colitis
  4. Define the role of Hes1 in colon epithelial homeostasis, immunity, and carcinogenesis
  5. Explore the function of aberrant Notch signaling in leukemia micro-environment;
  6. Develop a deeper understanding of pathophysiology of pancreatic cancer biomarkers (including PrP, Notch, and CRABP-II) in pancreatic cancer metabolism, metastasis and chemo-resistance.

Her research employs a combination of tools including genetically modified animal models, glycomics, state-of-the-art intravital microscopy, scRNA-seq, pre-clinical models of mobilization and transplantation, and digital RNA counting and spatial profiling of human cancer tissues. Dr. Zhou’s clinical research focuses on the application of cutting-edge molecular diagnostic tools in infectious diseases and transfusion medicine.

External Appointments

Title
Medical Director, Molecular Diagnostics Lab
Organization/Publication
University Hospitals Cleveland Medical Center

Publications

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Education

Degree
Doctor of Medicine
Institution
Shanghai Medical University
Degree
Doctor of Philosophy
Institution
State University of New York
Area of Study
Molecular and Cell Biology

Residencies, Internships and Fellowships

Institution
University of Michigan Hospitals and Health Centers
Area of Study
Residency, Anatomic and Clinical Pathology
Institution
University of Michigan Hospitals and Health Centers
Area of Study
Fellowship, Hematology - Pathology

Additional Information