Michael R. Jacobs, MBBS

Professor
Department of Pathology
School of Medicine
Professor
Department of Medicine
School of Medicine

Research Information

Research Interests

  • Antimicrobial Susceptibility Testing
  • Streptococcus Pneumoniae
  • Haemophilus Influenzae
  • Respiratory Tract Infections

Professional Memberships

Royal College of Pathologists
American Board of Medical Microbiology

External Appointments

University Hospitals Cleveland Medical Center, Director, Medical Microbiology
University Hospitals Cleveland Medical Center, Director, UHLSF-Chagrin

Publications

  • Dowell SF, Butler JC, Giebink GS, Jacobs MR, Jernigan D, Musher DM, Rakowski A, Schwartz B, the DRSPTWP (1999). Acute otitis media: management and surveillance in an era of pneumococcal resistance - a report from the Drug Resistant Streptococcus pneumoniae Therapeutic Working Group. Pediatr Infect Dis J 18, 1-9.
  • Heffelfinger JD, Dowell SF, Jorgensen JH, Klugman KP, Mabry LR, Musher DM, Plouffe JF, Rakowsky A, Schuchat A, Whitney CG and DRSP TWG Members (2000). Management of community-acquired pneumonia in the era of pneumococcal resistance: a report from the Drug-Resistant Streptococcus pneumoniae Therapeutic Working Group. Arch Intern Med 160, 1399-408.
  • Jacobs MR, Appelbaum PC, The Laser Group (2000). Susceptibility of 1100 Streptococcus pneumoniae strains isolated in 1997 from seven Latin American countries. Int J Antimicrobial Agents16 17-24.
  • Syrogiannopoulos G, Ronchetti F, Dagan R, Grivea I, Ronchetti MP, Porat N, Davies TA, Ronchetti R, Appelbaum PC, Jacobs MR (2000). Mediterranean clone of penicillin-susceptible, multidrug-resistant serotype 6B Streptococcus pneumoniae in Greece, Italy and Israel. Int J Antimicrobial Agents16, 219-224.
  • Nagai K, Davies TA, Pankuch GA, Dewasse BE, Jacobs MR, Appelbaum PC (2000). In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae. Antimicrob Agents Chemother 44, 2740-2746.
  • Tait-Kamradt A, Davies T, Appelbaum PC, Ddepardieu F, Courvakin P, Petipas J, Wondrack L, Walker A, Jacobs MR, Sutcliffe J (2000). Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America. Antimicrob Agents Chemother 44, 3395-3401.
  • Joloba ML, Bajaksouzian S, Jacobs MR (2000). Evaluation of etest for susceptibility testing of Mycobacterium tuberculosis. J Clin Microbiol 38, 3834-3836.
  • Credito KL, Lin G, Pankuch GA, Bajaksouzian S, Jacobs MR, Applebaum PC (2000). Susceptibility of Haemophilus Influenzae and Moraxella Catarrhalis to ABT 773 compared to eleven other agents. Antimicrob Agents Chemother 45, 67-72.
  • Palavecino EL, Riedel I, Berrios X, Bajaksouzian S, Johnson D, Kaplan E, Jacobs MR (2001). Prevalence and mechanisms of macrolide resistance in Streptococcus pyogenes in Santiago, Chile. Antimicrob Agents Chemother 45, 339-341.
  • Dagan R, Hoberman A, Johnson C, Leibovitz EL, Arguedas A, Rose FV, Wynne BR, Jacobs MR (2001). Bacteriologic and clinical efficacy of high dose amoxicillin/clavulanate in children with acute otitis media. Pediatr Infect Dis J 20, 829-837.
  • Fendrick AM, Saint S, Brook I, Jacobs MR, Pelton S, Sethi S (2001). Diagnosis and treatment of upper respiratory tract infections in the primary care setting. Clin Ther 23, 1683-1706.
  • Jacobs MR, Weinberg W (2001). Evidence-based guidelines for treatment of bacterial respiratory tract infections in the era of antibiotic resistance. Manag Care Interface 14, 68-80.
  • Jacobs MR, Palavecino E, Yomtovian R (2001). Don't bug me: the problem of bacterial contamination of blood components-challenges and solutions. Transfusion 41, 1331-1334.
  • Jacobs MR (2001). Optimisation of antimicrobial therapy using pharmacokinetic and pharmacodynamic parameters. Clin Microbiol Infect 7, 589-596.
  • Joloba ML, Windau A, Bajaksouzian S, Appelbaum PC, Hausdorff WP, Jacobs MR (2001). Pneumococcal conjugate vaccine serotypes of Streptococcus pneumoniae isolates and the antimicrobial susceptibility of such isolates in children with otitis media. Clin Infect Dis 33, 1489-1494.
  • Joloba ML, Bajaksouzian S, Palavecino E, Whalen C, Jacobs MR (2001). High prevalence of carriage of antibiotic-resistant Streptococcus pneumoniae in children in Kampala Uganda. Int J Antimicrob Agents 17, 395-400.
  • Jones RN, Pfaller MA, Jacobs MR, Appelbaum PC, Fuchs PC (2001). Cefditoren in vitro activity and spectrum: a review of international studies using reference methods. Diagn Microbiol Infect Dis 41, 1-14.
  • Lee N, Song J, Kim S, Peck KR, Ahn KM, Lee SI, Yang Y, Li J, Chongthaleong A, Tiengrim S, Aswapokee N, Lin TY, Wu JL, Chiu CH, Lalitha MK, Thomas K, Cherian T, Perera J, Yee TT, Jamal F, Warsa UC, Van PH, Carlos CC, Shibl AM, Jacobs MR, Appelbaum PC (2001). Carriage of antibiotic-resistant Pneumococci among Asian children: A multinational surveillance by the Asian Network for Surveillance of Resistant Pathogens (ANSORP). Clin Infect Dis 32, 1463-1469.
  • Nagai K, Shibasaki Y, Hasegawa K, Davies TA, Jacobs MR, Ubukata K, Aappelbaum PC (2001). Evaluation of PCR primers to screen for Streptococcus pneumoniae isolates and ß-lactam resistance, and to detect common macrolide resistance determinants. J Antimicrobial Chemother 48, 915-918.
  • Palavecino EL, Riedel I, Berrios X, Bajaksouzian S, Johnson D, Kaplan E, Jacobs MR (2001). Prevalence and mechanisms of macrolide resistance in Streptococcus pyogenes in Santiago, Chile. Antimicrob Agents Chemother 45, 339-341.
  • Sapatnekar S, Wood EM, Miller JP, Jacobs MR, Arduino MJ, McAllister SK, Kellum ME, Roth V, Yomtovian R (2001). Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report. Transfusion 41, 1426-1430.
  • Share L, Chaikin S, Pomeranets S, Kiwi R, Jacobs M, Fanaroff AA (2001). Implementation of guidelines for preventing early onset group B streptococcal infection. Semin Perinatol 25, 107-113.
  • Clark CL, Kanagi K, Davies TA, Dewasse B, Jacobs MR, Appelbaum PC (2001). Single- and multi-step selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin. Clin Microbiol Infect, in press.
  • Nagai K, Appelbaum PC, Davies TA, Kelly LM, Hoellman DB, Andrasevic AT, Drulalska L, Hryniewicz W, Jacobs, MR, Kolman J, Micileveciene J, Pana M, Setchanova L, Thege, MK, Hupkova H, Trupl J, Urbaskova P (2002). Susceptibility to telithromycin and 6 other agents, and the prevalence-detection of macrolide resistance due to L4 ribosomal protein mutation among 992 Streptococcus pneumoniae isolates from 10 Central and Eastern European countries. Antimicrob Agents Chemother 46, 371-377.
  • Nagai K, Appelbaum PC, Davies TA, Kelly LM, Hoellman DB, Andrasevic AT, Drulalska L, Hryniewicz W, Jacobs MR, Kolman J, Miciuleveciene J, Pana M, Setchanova L, Thege MK, Hupkova H, Trupl J, Urbaskova P (2002). Susceptibility to telithromycin in 1011 Streptococcus pyogenes isolates from 10 Central and Eastern European countries. Antimicrob Agents Chemother 46, 546-549.
  • Nagai K, Davies TA, Jacobs MR, Appelbaum PC (2002). Effects of amino acid alterations in penicillin- binding proteins 1a, 2b, and 2x on penicillin-binding protein (PBP) affinity of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate and –resistant pneumococci. Antimicrob Agents Chemother 46, 1273-1280.

Education

Degree
Diploma
Institution
University of the Witwatersrand
Area of Study
Public Health
Year Received
1976
Degree
Diploma
Institution
University of the Witwatersrand
Area of Study
Tropical Medicine & Hygiene
Year Received
1974
Degree
Bachelor of Medicine, Bachelor of Surgery
Institution
University of the Witwatersrand
Year Received
1971

Residency

Fellowship in Anatomic and Clinical Pathology, University Hospitals of Cleveland
Fellowship in Pathology, College of Medicine in South Africa
Residency in Anatomic and Clinical Pathology, University of Witwatersrand, Faculty of Health Sciences and South African Institute for Medical Research
Internship in Medicine and Surgery, Johannesburg Hospital/University of the Witwatersrand

Additional Information