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School of
Medicine

Pathology

Faculty

Faculty

Wei Xin, M.D., Ph.D.

Wei Xin, M.D., Ph.D.

Associate Professor

wei.xin@case.edu (216) 844-4976 (o) (216) 368-0494 (f)

Dr. Wei Xin graduated from Shanghai Medical University (1991) and finished his urology residency in Shanghai First People's hospital. Then he came to USA to study molecular mechanism of hepatitis B virus and subsequently received a PhD from the State University of New York at Buffalo (1998).

Dr. Wei Xin received his AP/CP pathology training in University of Michigan, Ann Arbor. He also completed his fellowship training of surgical pathology with subspecialty of GI/liver pathology in University of Michigan, in addition, he also received pancreatic pathology training in GI/liver division of Johns Hopkins University. He also received Rodger C. Haggitt GI Pathology Society award for best resident presentation (2003), and M.R. Abell House Officer Award for the outstanding and exemplary achievement in the discipline of pathology (2004).

Before Dr. Xin joined the faculty as assistant professor at Case Western Reserve University, he was the faculty of the Department of Pathology as lecturer in University of Michigan and served as the GI pathologist and associated medical director of Acupath Laboratory Inc (Plainview, NY).

Currently he is an associate professor and the director of autopsy, specializes in GI/liver pathology. His research has been on GI tract carcinogenesis with mice model and translational research, with dozens of prestigious publications. Provides histology services for multiple investigators in the cancer center and the university. 

Research summary

Dr. Xin's current research interests are non-neoplastic GI disease and GI tract neoplasm especially pancreatic tumors, hepatomas and gastric tumors.

Selected Publictations

  1. Shuiliang Yu, Neetha Parameswaran, Ming Li, Yiwei Wang, Miachael W. Jackson, Huiping Liu, Wei Xin, Lan Zhou. CRABP-II enhances pancreatic cancer cell migration and invasion by stabilizing interleukin 8 expression.Oncotarget. 2016 Dec 26. doi: 10.18632/oncotarget.14194.

  2. Yiwei Wang,Dan Huang,Kai-Yuan Chen,Min Cui,Weihuan Wang,Xiaoran Huang,Amad Awadellah,Qing Li,  Ann Friedman,Luca Di Martino,  Fabio Cominelli,  Alex Miron, Ricky Chan,James Fox,Yan Xu, Xiling Shen,  Mathew Kalady,Sanford Markowitz,Ivan Maillard,John Lowe,Wei Xin and Lan Zhou. Fucosylation-deficiency Leads to Serrated Lesions and Colon Adenocarcinoma. Gastroenterology. 2017 Jan;152(1):193-205

  3. Yiwei Wang, Shuiliang Yu, Dan Huang, Min Cui, Huankai Hu, Barbara Osborn, Chaoyang Li, Wei Xin*, Lan Zhou*. Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1. American Journal of Pathology, 2016 Nov;186(11):2945-2956. *shared senior authorship
  4. Min Cui, Amad Awadallah, Wendy Liu, Lan Zhou and Wei Xin. Loss of Hes1 Differentiates Sessile Serrated Adenoma/polyp from Hyperplastic polyp. American Journal of Surgical Pathology. American Journal of Surgical Pathology. 2016 Jan;40(1):113-9

  5. Alex Rodriguez-Palacios, Tomohiro Kodani, Lindsey Kaydo, Davide Pietropaoli, Daniele Corridoni, Scott Howell, Jeffry Katz, Wei Xin, Theresa T. Pizarro, Fabio Cominelli.  Stereomicroscopic 3D-pattern profiling of murine and human intestinal inflammation reveals unique structural phenotypes. Nature Communication 2015 Jul 8. 6:7577

  6. Wenbin Xiao, Hong Hong, Shuiliang Yu, Lan Zhou and Wei Xin. Over-expression of CRABP2 is a Diagnostic Marker of Pancreatic Ductal Adenocarcinoma. Human Pathology, Human Pathology. 2014 June 45(6):1177-83

  7. Wenbin Xiao, Hong Hong, Amad Awadallah, Lan Zhou and Wei Xin. Utilization of CDX2 Expression in Diagnosing Pancreatic Ductal Adenocarcinoma and Predicting Prognosis. Plos One, 2014 Jan 29;9(1):e86853

  8. Huankai Hu, Lan Zhou, Amad Awadallah and Wei Xin. Significance of Notch1 Signaling Pathway in Human Pancreatic Development and Carcinogenesis. Applied Immunohistochemistry & Molecular Morphology.2013 May;21(3):242-7.

  9. Chaoyang Li, Shuiliang Yu, Jinghua Xu, Amber A Petrolla, Fumihiko Nakmura, Shaoman Yin, Neena Singh, Thomas Stossel, Alan Tartakoff, Derek Abbot, Wei Xin* and Man-sun Sy*. Binding of Prion Pro-protein to Filamin A Disrupts Cytoskeletal organization and Signaling that Provides Growth Advantage to Human Pancreatic Ductal Carcinomas. Journal of Clinical Investigation, 2009 Aug; 119(9):2725-2736
    *shared senior authorship

  10. Amber A Petrolla, Jeffrey A Katz and Wei Xin. The Clinical Significance of Focal Enhanced Gastritis in Adults with Isolated Terminal Ileitis, Journal of Gastroenterology. 2008 Jul; 43(7):524-530.

  11. Wei Xin and Joel K. Greenson. The Clinical Significance of Focally Enhanced Gastritis. American Journal of Surgical Pathology. 2004 Oct; 28(10):1347-1351.

  12. Wei Xin, Kim J. Yun, Francesca Ricci, Marianna Zahurak, Wanglong Qiu, Gloria H. Su, Charles J. Yeo, Scott E. Kern, Ralph H. Hruban and Christine A. Iacobuzio-Donahue. Evaluation of MKK4 Expression in Pancreatic Cancer using Tissue Microarray Technology: Relationship to Genetic status, Metastasis and Prognosis. Clinical Cancer Research, 2004 Dec; 10: 8516-8520.

  13. Wei Xin, Pamela I Brown and Joel K Greenson. The Clinical Significance of Focal Active Colitis in Pediatric Patients. The American Journal of Surgical Pathology. 2003 Aug; 27(8): 1134-1138.

Please see my full list of publications at the link below:

https://www.ncbi.nlm.nih.gov/sites/myncbi/1Da_cnLe679A8/bibliography/43366187/public/?sort=date&direction=descending