Robert (Rob) P. Igo, Jr., PhD

Assistant Professor
Department of Population and Quantitative Health Sciences
School of Medicine

Robert (Rob) P. Igo, Jr., PhD, passed away over the weekend of July 18, 2020.

Please read our memorial piece about our dear colleague here

 

Teaching Information

Courses Taught

EPBI 452: Statistical Methods for Genetic Epidemiology
EPBI 502: Genetic Epidemiology Seminar
Statistical Programming

Research Information

Research Interests

I am interested in developing and applying statistical methods to identify genetic factors influencing complex traits. I participate in collaborative research projects focused on Fuchs endothelial corneal dystrophy, kidney disease in diabetes, age-related macular degeneration and susceptibility to tuberculosis.

Professional Memberships

American Society of Human Genetics
International Genetic Epidemiology Society
Association for Research in Vision and Ophthalmology

Publications

  1. Craig, JE, Han, X, Qassim, A, Hassall, M, Cooke Bailey, JN, Kinzy, TG, Khawaja, AP, An, J, Marshall, H, Gharahkhani, P, Igo, RP Jr, Graham, SL, Healey, PR, Ong, JS, Zhou, T, Siggs, O, Law, MH, Souzeau, E, Ridge, B, Hysi, PG, Burdon, KP, Mills, RA, Landers, J, Ruddle, JB, Agar, A, Galanopoulos, A, White, AJR, Willoughby, CE, Andrew, NH, Best, S, Vincent, AL, Goldberg, I, Radford-Smith, G, Martin, NG, Montgomery, GW, Vitart, V, Hoehn, R, Wojciechowski, R, Jonas, JB, Aung, T, Pasquale, LR, Cree, AJ, Sivaprasad, S, Vallabh, NA, NEIGHBORHOOD consortium, UK Biobank Eye and Vision Consortium, Viswanathan, AC, Pasutto, F, Haines, JL, Klaver, CCW, van Duijn, CM, Casson, RJ, Foster, PJ, Khaw, PT, Hammond, CJ, Mackey, DA, Mitchell, P, Lotery, AJ, Wiggs, JL, Hewitt, AW, MacGregor, S. Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nat. Genet. 2020; 52 (2): 160-166. PubMed PMID:31959993 .
  2. Zein, J, Gaston, B, Bazeley, P, DeBoer, MD, Igo, RP Jr, Bleecker, ER, Meyers, D, Comhair, S, Marozkina, NV, Cotton, C, Patel, M, Alyamani, M, Xu, W, Busse, WW, Calhoun, WJ, Ortega, V, Hawkins, GA, Castro, M, Chung, KF, Fahy, JV, Fitzpatrick, AM, Israel, E, Jarjour, NN, Levy, B, Mauger, DT, Moore, WC, Noel, P, Peters, SP, Teague, WG, Wenzel, SE, Erzurum, SC, Sharifi, N. HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma. Proc. Natl. Acad. Sci. U.S.A. 2020; 117 (4): 2187-2193. PubMed PMID:31932420 PubMed Central PMC6995013.
  3. Igo, RP Jr, Kinzy, TG, Cooke Bailey, JN. Genetic Risk Scores. Curr Protoc Hum Genet 2019; 104 (1): e95. PubMed PMID:31765077 PubMed Central PMC6941594.
  4. Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser, MA, Allingham, RR, Aung, T, Van Der Heide, CJ, Taylor, KD, Rotter, JI, Wang, SJ, Bonnemaijer, PWM, Williams, SE, Abdullahi, SM, Abu-Amero, KK, Anderson, MG, Akafo, S, Alhassan, MB, Asimadu, I, Ayyagari, R, Bakayoko, S, Nyamsi, PB, Bowden, DW, Bromley, WC, Budenz, DL, Carmichael, TR, Challa, P, Chen, YI, Chuka-Okosa, CM, Cooke Bailey, JN, Costa, VP, Cruz, DA, DuBiner, H, Ervin, JF, Feldman, RM, Flamme-Wiese, M, Gaasterland, DE, Garnai, SJ, Girkin, CA, Guirou, N, Guo, X, Haines, JL, Hammond, CJ, Herndon, L, Hoffmann, TJ, Hulette, CM, Hydara, A, Igo, RP Jr, Jorgenson, E, Kabwe, J, Kilangalanga, NJ, Kizor-Akaraiwe, N, Kuchtey, RW, Lamari, H, Li, Z, Liebmann, JM, Liu, Y, Loos, RJF, Melo, MB, Moroi, SE, Msosa, JM, Mullins, RF, Nadkarni, G, Napo, A, Ng, MCY, Nunes, HF, Obeng-Nyarkoh, E, Okeke, A, Okeke, S, Olaniyi, O, Olawoye, O, Oliveira, MB, Pasquale, LR, Perez-Grossmann, RA, Pericak-Vance, MA, Qin, X, Ramsay, M, Resnikoff, S, Richards, JE, Schimiti, RB, Sim, KS, Sponsel, WE, Svidnicki, PV, Thiadens, AAHJ, Uche, NJ, van Duijn, CM, de Vasconcellos, JPC, Wiggs, JL, Zangwill, LM, Risch, N, Milea, D, Ashaye, A, Klaver, CCW, Weinreb, RN, Ashley Koch, AE, Fingert, JH, Khor, CC. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. JAMA 2019; 322 (17): 1682-1691. PubMed PMID:31688885 PubMed Central PMC6865235.
  5. Lewis, BA, Freebairn, L, Tag, J, Igo, RP Jr, Ciesla, A, Iyengar, SK, Stein, CM, Taylor, HG. Differential Long-Term Outcomes for Individuals With Histories of Preschool Speech Sound Disorders. Am J Speech Lang Pathol 2019; 28 (4): 1582-1596. PubMed PMID:31604025 .
  6. Waksmunski, AR, Grunin, M, Kinzy, TG, Igo, RP Jr, Haines, JL, Cooke Bailey, JN, International Age-Related Macular Degeneration Genomics Consortium. Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2019; 60 (12): 4041-4051. PubMed PMID:31560769 PubMed Central PMC6779289.
  7. Fan, BJ, Bailey, JC, Igo, RP Jr, Kang, JH, Boumenna, T, Brilliant, MH, Budenz, DL, Fingert, JH, Gaasterland, T, Gaasterland, D, Hauser, MA, Kraft, P, Lee, RK, Lichter, PR, Liu, Y, Moroi, SE, Myers, JS, Pericak-Vance, MA, Realini, A, Rhee, DJ, Richards, JE, Ritch, R, Schuman, JS, Scott, WK, Singh, K, Sit, AJ, Vollrath, D, Weinreb, RN, Wollstein, G, Zack, DJ, Haines, JL, Pasquale, LR, Wiggs, JL. Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis. JAMA Ophthalmol 2019; : . PubMed PMID:31436842 PubMed Central PMC6707005.
  8. Waksmunski, AR, Igo, RP Jr, Song, YE, Cooke Bailey, JN, Laux, R, Fuzzell, D, Fuzzell, S, Adams, LD, Caywood, L, Prough, M, Stambolian, D, Scott, WK, Pericak-Vance, MA, Haines, JL. Rare variants and loci for age-related macular degeneration in the Ohio and Indiana Amish. Hum. Genet. 2019; 138 (10): 1171-1182. PubMed PMID:31367973 PubMed Central PMC6745026.
  9. Halladay, CW, Hadi, T, Anger, MD, Greenberg, PB, Sullivan, JM, Konicki, PE, Peachey, NS, Igo, RP Jr, Iyengar, SK, Wu, WC, Crawford, DC, VA Million Veteran Program. Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. AMIA Jt Summits Transl Sci Proc 2019; 2019 : 153-162. PubMed PMID:31258967 PubMed Central PMC6568141.
  10. Laville, V, Kang, JH, Cousins, CC, Iglesias, AI, Nagy, R, Cooke Bailey, JN, Igo, RP Jr, Song, YE, Chasman, DI, Christen, WG, Kraft, P, Rosner, BA, Hu, F, Wilson, JF, Gharahkhani, P, Hewitt, AW, Mackey, DA, Hysi, PG, Hammond, CJ, vanDuijn, CM, Haines, JL, Vitart, V, Fingert, JH, Hauser, MA, Aschard, H, Wiggs, JL, Khawaja, AP, MacGregor, S, Pasquale, LR, UK Biobank, International Glaucoma Genetics Consortium, NEIGHBORHOOD Consortium. Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes. Am. J. Ophthalmol. 2019; 206 : 245-255. PubMed PMID:31121135 PubMed Central PMC6864262.

Publishing impact

Metrics from Web of Science/publons and Scopus/SciVal:

  • H-index: 26
  • Total publications: 71
  • Total citations: 2,359
  • Publications in top-tier journals: 61%  
  • Collaborative publishing national/international: 40%/60% 

Editorial roles

Occasional peer review for the following: 

  • Molecular Cell
  • Genetic Epidemiology
  • BMC Genetics
  • Expert Reviews in Ophthalmology
  • Frontiers in Applied Genetic Epidemiology
  • International Journal of Tuberculosis and Lung Diseases
  • PLoS ONE
  • Molecular Genetics and Genomics
  • Molecular Vision
  • Bioinformatics
  • Human Genetics
  • Ophthalmic Genetics
  • Journal of the American Society of Nephrology
  • Scientific Reports
  • Kidney International
  • Kidney International Reports
  • Genome Research
  • PLoS Genetics  

Education

B.A.
Mathematics
Oberlin College
1988
Ph.D.
Anatomy (Molecular Biology)
University of Utah
1997
M.S.
Biostatistics
University of Washington
2005

Additional Information

Contributions to science:

  • Genome-wide analyses that shed light on the mechanisms of Fuchs corneal endothelial dystrophy (FECD) progression and may help clinicians predict disease severity and rate of progression from genetic data 
  • Multiple analyses on one of the largest available primary open-angle glaucoma (POAG) case-control samples, which led to the discovery of new genetic determinant for POAG and XFS
  • Collaborated in identifying a variety of new genes associated with age-related macular degeneration (AMD) thereby clarifying the role of the human genome in AMD
  • Identified several genomic loci that may be involved in the pathogenesis of diabetic neuropathy

Active grants:

  • Alcon Research, Ltd.: Genetic susceptibility to contact lens-related microbial keratitis
  • VA I01: Genetic risk for AMD in diverse veteran populations
  • NIH/NIDCD 5R01: Biological and behavioral markers of persistent speech sound disorders
  • NIH/NIA RF1: Protective genetic variants for Alzheimer’s disease in the Amish
  • NIH/NEI R01: Unraveling the genetic architecture of diabetic retinopathy in South India
  • NIH/NIDCD R01: Genetic causes of severe development speech sound disorder in families
  • NIH/NEI R01: Genetic and environmental risk factors for exfoliation syndrome in glaucoma
  • NIH/NIAID R01: Genetics of TB resistance in HIV-positive subjects
  • R01: The NEIGHBORHOOD Consortium for POAG Genetics

Student and mentee totals, over Case Western Reserve University career/full academic:

  • Master’s: 15
  • PhD: 3
    • A sampling of CWRU Master’s and PhD graduates’ current careers:  
    • CWRU, Senior Research Associate
    • Hospital Corporations of America, Statistical Analyst (MS mentee)
    • Explorys, Inc., Director of Platform Engineering (MS mentee)