Clinical Director and Vice Chair for Clinical Affairs
Under the direction of Dr. Mitchell Machtay, deputy chairman of NRG Oncology, the Department of Radiation Oncology has been transformed into a top clinical research department leading in both national trials as well as investigator-initiated trials.
The Department of Radiation Oncology has an exceptionally strong medical residency program led by Drs. Mitchell Machtay and Tithi Biswas. Our four-year program was recently re-accredited by the Accreditation Council for Graduate Medical Education (ACGME). Department faculty teach numerous medical students from Case Western Reserve University, as well as visiting medical students from around the country.
The Medical Physics and Dosimetry Division of the Department of Radiation Oncology has grown to keep pace with the expansion of services at University Hospitals as well as providing comprehensive physics and dosimetry support to multiple community cancer treatment facilities. The development and implementation of new treatment technologies are critical to maintaining the level of patient care at the state-of-the-art, and the further advancement of the Department. Current physics research efforts in automatic image segmentation and registration, respiratory gating, Intensity Modulated Radiation Therapy (IMRT) optimization and adaptive targeting, as well as radionuclide dosimetry, have become focus areas to expand and improve the leading-edge treatment technology.
But improvements in treatment delivery and clinical impact are only part of the story. Laboratory research on the fundamental biological mechanisms of the interaction of radiation with tissue provides the proving ground for therapeutic interventions. Faculty members in the Division of Radiobiology are investigating novel mechanisms of cancer development and treatment relating to their interests in: DNA damage repair; Radiosensitization; Signaling in cancer cells; Photodynamic therapy; Hypoxia; Synthetic lethality; and other pertinent areas.
These investigations complement and drive our clinical translational research. Together, clinicians, physicists, and scientific researchers all contribute to the dynamic growth of a department at the forefront of patient care in an evolving field.