Heart, Lung and Blood (HLB) Summer Research Program

2018 Sources Poster Session- HLB

Approximate Program Dates: June 6- August 5, 2022

For students on a quarter-system, we will provide some flexibility with your program dates.

View a sample summer schedule.

Overview

The Heart, Lung and Blood Summer Research Program is designed to engage 12 diverse undergraduates and 8 medical students in state-of-the art biomedical research in cardiovascular, pulmonary, hematological and sleep disorders research.

Students who belong to groups underrepresented in biomedical sciences are eligible to apply. In general, this includes students who are African American, American Indian/Alaska Native, Latino, Puerto Rican, Pacific Islanders, students from low-income families, or those with disabilities as defined by the NIH. Please note that you must be a US citizen or Permanent resident to participate.

Participants will enjoy weekly seminars that highlight research in these disciplines, as well as activities that encourage interaction among all students engaged in summer research.

The program will culminate in a poster session required for all undergraduates and non-CWRU medical students. CWRU medical students will present their work in the subsequent CWRU Lepow Day event.

Research Mentors

After acceptance, participants will be matched with a faculty member whose research is of interest to the student. Only faculty of Case Western Reserve University may serve as research mentors. See list of possible mentors below.

 

Mentor

Research Interest

 W. Henry Boom, MD

 Identifying molecules of M. tuberculosis that interfere with MHC-II antigen processing.

Farren Briggs, PhD Sc.M Understanding the etiology and pathology of MS from the micro- to the macro-level. 

 Matthias Buck, PhD

 Protein-Protein Interactions in Cell Signaling of small GTPases, Plexin and Eph receptors.

Sudha Chakrapani, PhD

 Understanding the role of structure and dynamics in the functioning of ion channels.

Thomas Dick, PhD

 Control of Respiration and Sympathetic Activity.

 Mitchell Drumm, PhD

 Understanding how variants in the genome influence the course of disease for CF patients and how the CF genome adapts to the disease.

 George Dubyak, PhD

 Signal transduction by extracellular nucleotides and inflammasomes in innate immunity and inflammation.

Yolanda Fortenberry, PhD

 

 Developing RNA-based therapeutic molecules for treating individuals with blood-related diseases.

Stanton Gerson, MD

 Mesenchymal stem cells as a therapeutic infusion for blood stem cell transplantation and for the correction of genetic disorders.

 Craig Hodges, PhD

 The loss of CFTR leads to the intestinal dysfunction and reduced growth phenotypes associated with CF.

 Thomas Kelley, PhD

 Identifying a mechanistic link between the loss of CFTR function and altered cell-signaling control in CF airway epithelial cells.

 Alan Levine, PhD

 Host Defense: Toggling between immune tolerance and immune protection.

 Stephen Lewis, PhD

 Molecular mechanisms underlying impaired biologic pathways such as respiratory control and pharmacologic interventions.

 Christopher Longenecker, MD

 Cardiovascular Medicine focusing on the role of chronic immune activation and inflammation in mediating cardiometabolic risk.

 Peter MacFarlane, PhD

 Understanding how the neurobiology of breathing is modified by early life experiences, particularly related to clinical scenarios commonly experienced by preterm infants.

 Andrei Maiseyeu, PhD

 Developing nanotechnology tools to better understand cardiometabolic diseases such as atherosclerosis, type 2 diabetes and obesity.

Sarah Markt, ScD, MPH

Integrating molecular, lifestyle, and clinical epidemiology to study risk factors for the initiation and progression of cancer, with the primary goal to translate research findings into direct application for primary and secondary cancer prevention. 

 Shigemi Matsuyama, DVM, PhD

 Cancer Cell Biology; Cell Death Regulation; Cell Penetrating Peptide.

 Monica Montano, PhD

 Targeting angiogenesis in hormone dependent cancers. 

 Ting-Wei Mu, PhD

 Proteostasis of membrane proteins in health and disease.

 Lalitha Nayak, MD

 The anti-thrombotic effects of bortezomib are determined by KLF2, part of a family of Kruppel-like factors—master regulators of vascular health.

 Marvin Nieman, PhD

 Role of the interaction between protease activated receptors 1 and 4 (PAR1 and PAR4) in the activation of platelets by alpha-thrombin and the subsequent signaling of G-proteins by second messenger signaling molecules.

Patrick Osei-Owusu, PhD FAHA The integration and regulation of cell signaling mechanisms that facilitate the physiological and pathophysiological effects of various hormones, neurotransmitters and mechanical stimuli in the cardiovascular and renal systems. 

 Jonathan Stamler, MD

 Developing new drugs for treatment of heart, lung and blood disorders and complications of blood transfusion.

Julian Stelzer, PhD

 Understanding the molecular mechanisms that govern the regulation of contractile function in the cardiac sarcomere.

 Focco Van den Akker, PhD

 The molecular intricacies of enzyme mechanism and receptor activation and using that knowledge to develop inhibitors and activators for pharmaceutical purposes.

Zhenghe (John) Wang, PhD

Defining mechanisms of oncogenesis at the molecular, regulatory and phenotypic levels and translating these discoveries to new cancer therapies.

 Lan Zhou, MD PhD

 Understanding how fucosylation affects Notch-dependent regulation of hematopoietic stem cell proliferation, early myeloid lineage specification and hematopoietic stem cell niche maintenance.

Stipend

$1750 per month, minimum two months ($3500). Students who participate for longer periods will have additional pro-rated stipend support. We will provide up to $500 in travel expenses from your home to Cleveland (and back!). Some support toward dormitory housing (approximate housing cost before support: $1700) may be available.

How to Apply

To be considered for the program, you must complete the online application, submit three letters of recommendation, and supply unofficial transcript from your undergraduate institution. Please note that an official transcript will be required if accepted into the program.

Application

To start your application to the Heart, Lung and Blood (HLB) Summer Research Program, first create your account through the online application portal. Once logged in the School of Medicine application, under the Program Details section, select the Degree Type: Special ProgramsProgram: Heart, Lung and Blood Summer Research, and the term to proceed.  

Letters of Recommendation

The recommendation process will also occur online. Please be sure to have the emails of your recommenders available. Once you add your recommenders, they will be notified to submit their recommendation online. 

Transcripts

Unofficial transcripts from your undergraduate institution that you currently or have attended should be uploaded in the transcript section of the online application. Medical student applicants should substitute a letter from your medical school confirming status as a current student in good standing in lieu of transcripts.  You will be required to submit official transcripts if you are accepted to CWRU HLB.  Medical student status letters can be emailed to Malana Bey at mcb19@case.edu or mailed to:

Office of Graduate Education
School of Medicine Room TG1
Case Western Reserve University
10900 Euclid Avenue
Cleveland, OH 44106

 

Deadline

The application deadline is March 15, 2022. Seniors who are graduating in May or June 2022 are not eligible for this program. 

 

Apply Now

 

Contact:

Monica Montano, PhD

Director

Tel: 216-368-3378

Email: monica.montano@case.edu

Malana Bey,

HLB Program Administrator

Tel: 216-368-5655

Email: malana.bey@case.edu