CONTACT INFORMATION
Phone: (216) 844-3544
Fax: (216) 844-5922
Email: agata.exner@case.edu
Office: Bishop s606, 11100 Euclid Ave, Cleveland, OH 44106-7222
EDUCATION
Ph.D. in Biomedical Engineering, Case Western Reserve University
M.S. in Biomedical Engineering, Case Western Reserve University
B.S. in Biomedical Engineering, Case Western Reserve University
ACTIVE RESEARCH
Development of Injectable, Ultrasound-modulated Drug Depot
Solvent-based local chemotherapy system is injected into tissue and creates a storage depot for drug-loaded, tumor-targeted nanoparticles which can be released through diffusion, degradation or mecahnical stimulation, which can create “on demand” drug release and increase drug uptake. This device has applications in intratumoral chemotherapy and adjuvant treatment to minimally invasive, ablative approaches.
Enhancement of Tumor RF Ablation by Nontoxic Thermosensitizer Pretreatment |
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Unresolved issues with image guided RF ablation have been shown to be causes of incomplete treatments leading to local tumor recurrece. We are investigating an approach that uses a nontoxic, systemic thermosensitizer before the ablation to ensure a reproducible, successful treatment.
Ultrasound-activated drug delivery nanoparticles
formulation of nanoparticle drug carriers that can be selectively disrupted by ultrasound at different frequencies.
POTENTIAL IMPACT
SELECTED PUBLICATIONS
Krupka TM, Weinberg BD, Ziats NP, Haaga JR, Exner AA. Injectable Polymer Depot Combined With Radiofrequency Ablation for Treatment of Experimental Carcinoma in Rat. Invest Radiol. 2006 Dec;41(12):890-897.
FIELDS
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