CONTACT INFORMATION
| Phone: (216) 368-3336 |
| Fax: (216) 368-3419 |
| Email: eckhard.jankowsky@case.edu |
Office:Wood W 447, 10900 Euclid Ave, Cleveland, OH 44106
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EDUCATION
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Ph.D. in Chemistry/Biochemistr,y
Dresden Institute of Technology, Dresden, Germany
M.S. in Chemistry
Dresden, Institute of Technology, Dresden, Germany |
ACTIVE RESEARCH
RNA Protein Assemblies
Understand the principles that underlie the design and function of complexes that contain RNA and proteins. Specific focus: function of RNA helicases - the motors and switches that facilitate changes in shape and composition of RNA-protein complexes.
Single Molecule Fluorescence
Investigate changes in the shape of individual biological complexes.
POTENTIAL IMPACT
Our research illuminates functional principles of biological nano-assemblies. This knowledge will faciliate the rational design of nano-assemblies for therapeutic intervention or for biology-inspired nanotechnological complexes.
SELECTED PUBLICATIONS
Fairman ME, Maroney PA, Wang W, Bowers HA, Gollnick P, Nilsen TW, Jankowsky E. "Protein displacement by DExH/D “RNA helicases” without duplex unwinding."
Science 304, 730-734 (2004)
Yang Q, Jankowsky E. "ATP- and ADP-dependent modulation of RNA unwinding and strand annealing activities by the DEAD-box protein DED1." Biochemistry. 44, 13591-13601 (2005)
Jankowsky E, Fairman ME, Yang Q. "RNA helicases: versatile ATP-driven nanomotors." J. Nanosci. Nanotech. 5, 1983-1989 (2005)
Bowers HA, Maroney PA, Fairman ME, Kastner B, Luhrmann R, Nilsen TW, Jankowsky E. "Discriminatory RNP remodeling by the DEAD-box protein DED1." RNA 12, 903-912 (2006)
FIELDS
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