NANOBOOK

	Marty Pagel Assistant Professor Biomedical Engineering Radiology, Macromolecular Science and Engineering
Contact | Eduction | Research | Potential Impact | Publications | Fields | Web Site

CONTACT INFORMATION

EDUCATION

ACTIVE RESEARCH   "Smart" molecular imaging probes Developing new MRI probes that detect enzymes and metabolites that react with the probes to change image signals. New MRI methods to Assess Tumor Angiogenesis Developing new nano-scale MRI probes and MR imaging methods to more accurately assess tumor vascular permeability characteristics, in order to improve the detection of tumor angiogenesis and assessment of anti-angiogenic therapies.

New MRI methods to Assess Osteoarthritis

Developing new MRI probes and MR imaging detection methods to more accurately assess loss of proteoglycans, which is an early biomarker of osteoarthritis.

POTENTIAL IMPACT

This research will enable the detection of enzymes and metabolites that are important biomarkers of many biological processes and disease states. This research will also enable the selective detection of multiple probes, which will provide opportunities to non-invasively assess molecular signatures of diseases.

SELECTED PUBLICATIONS

Yoo B, Pagel MD. A "smart" PARACEST MRI contrast agent to detect enzyme activity. J. Am. Chem. Soc., 2006, 128(43):14032-14033.

Yoo B, Pagel MD. A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe. Tetrahedron Lett, 2006, 47:7327-7330.

Pagel MD, Baldwin SJ, O’Neal JM, Ornberg RL, Davis TW, Kotyk JK, Merits of Multiple Contrast Agents and Pixel-by-Pixel Analyses for Detection of Early Changes in Vascular Permabilities in Murine Tumor Models Following Drug Therapy and/or Radiation Therapy.

Proc ISMRM 11:1250, 2003. Kotyk JJ, Pagel MD, Deppermann KL, Colletti RF, Hoffman NG, Yannakakis EJ, Das PK, Ackerman JJH, High-Throughput Determination of Oil Content in Corn Kernels Using Nuclear Magnetic Resonance Imaging. J Am. Oil Chem. Soc., 2005, 82:855-862.

FIELDS