case western reserve university



Melissa Knothe Tate

Associate Professor

Biomedical Engineering

Mechanical & Aerospace Engineering

Center for Multiscale Computational Modeling of Biomedical and Bio-inspired Systems

Contact | Eduction | Research | Potential Impact | Publications | Fields | Web Site

Phone: (216) 368-5884
Fax: (216) 368-4979

Office: Wickenden 319, 10900 Euclid Avenue, Cleveland, OH 44106


Ph.D. in Biomedical and Mechanical Engineering Swiss Federal Institute of Technology Zurich (ETH) (1997)

M.S. in Biomedical and Mechanical Engineering Swiss Federal Institute of Technology Zurich (ETH) (1994)

Dual B.S. in Biological Sciences and Mechanical Engineering Stanford University (1989)



Nano-microscale Fluid Dynamics in Biological Systems

Biological tissues have the capacity to adapt to changing environmental conditions throughout life. Pericellular fluid is a coupling medium for mechanical, chemical and electrical signal transmission to cells, the living component of the tissues.

This research program aims to elucidate the pericellular fluid environment and its effect on molecular transport between cells and the blood supply as well as mechanical signal transduction. Such knowledge can be applied to understand mechanisms of disease and aging and to reverse or prevent these processes at early stages in the disease process.

Engineering Optimization of Tissue Scaffolds to Steer Stem Cell Fate

In the human body, a number of healing processes recapitulate embryonic development. This program aims to optimize the design and manufacturing of rapid prototyped tissue templates to provide mechanical and chemical signals mimicking those prevailing in utero, with the goal to teach stem cells to build tissue.

Novel Bioactive Material Development

Fluid-structure interactions in nano-microscale systems are exploited to develop novel bioactive materials for wound healing and mechanically active fabrics.


This integration of biomedical, fluid dynamics and mass transport research at the nanoscale provides a platform for the translation of new insights and discoveries to the medical and materials sectors.


Anderson EJ, Kaliyamoorthy S, Iwan J, Alexander D, Knothe Tate ML. Nano-microscale models of periosteocytic flow show differences in stresses imparted to cell body and processes. Ann Biomed Eng. 2005 Jan;33(1):52-62.

Steck R, Tate ML. In silico stochastic network models that emulate the molecular sieving characteristics of bone.Ann Biomed Eng. 2005 Jan;33(1):87-94 Reilly GC, Knapp HF, Stemmer A, Niederer P, Knothe Tate ML.

Investigation of the morphology of the lacunocanalicular system of cortical bone using atomic force microscopy. Ann Biomed Eng. 2001 Dec;29(12):1074-81. "Anderson EJ, Falls TD, Sorkin AM, Knothe Tate ML.

The Imperative for Controlled Mechanical Stresses in Unraveling Cellular Mechanisms of Mechanotransduction. Biomed Eng Online. 2006 May 3;5(1):27"

Computation and Simulation