CONTACT INFORMATION
Phone: (216) 368-1697
Fax: (216) 368-3055
Email: pad5@case.edu
EDUCATION
ACTIVE RESEARCH
Cell Fission in Bacteria
Identify and study the proteins that make up and regulate the cell division apparatus in bacteria.
Oscillating Proteins in Bacteria
The min proteins spatio-temporally regulate assembly of the cell fission apparatus by rapid oscillatory movement between the cell ends. We study the mechanism of oscillation in vivo, and in vitro using small hydrophobic compartments.
Cell Shape Determination in Bacteria |
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Identify and study the proteins responsible for imposing/maintaining cell shape in non-spherical bacteria.
POTENTIAL IMPACT
The work is aimed at understanding the fundamental cell biological processes of cytokinesis (cell division) and cell shape determination at a molecular level.
SELECTED PUBLICATIONS
Thomas G. Bernhardt and Piet A. J. de Boer (2005) SlmA, a nucleoid-associated FtsZ binding protein required for blocking septal ring assembly over chromosomes in E.coli. Mol. Cell 18: 555-564.
Laura L. Lackner, David M. Raskin, and Piet A.J. de Boer (2003) ATP-dependent interactions between the Escherichia coli Min proteins and phospholipid membrane in vitro. J. Bacteriol. 185: 735-749.
FIELDS
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