Multiphoton Microscopy for Imaging Deeper, Wider, and Faster

Event Date:
December 6th 2:00 PM - 3:00 PM

Zoom Link:

Passcode: 989260


Seminar Title: Multiphoton Microscopy for Imaging Deeper, Wider, and Faster

Speaker: Chris Xu, PhD. 

IBM Chair Professor of Engineering

Director, School of Applied and Engineering Physics

The Mong Family Foundation Director, Cornell Neurotech – Engineering

Cornell University


Abstract: Multiphoton microscopy has changed how we visualize neurons by providing high-resolution, non-invasive imaging capability deep within intact brain tissue. Multiphoton imaging will likely play a major role in understanding how the brain works at the level of neural circuits. In this talk, in vivo structural and functional imaging of mouse brain using long wavelength excitation and three-photon microscopy will be presented. By quantitative comparison to two-photon microscopy, the application space where 3-photon microscopy outperforms conventional 2-photon microscopy will be defined. In addition, a number of interesting directions, including new laser sources, new spectral windows, optimum illumination schemes, etc., will be presented, and their impact on further improving the imaging depth, volume, or speed in biological tissues will be discussed.

About the Speaker: Dr. Chris Xu is the IBM Chair Professor of Engineering at Cornell University. He is the Director of the School of Applied and Engineering Physics, the Mong Foundation co-director of Cornell Neurotech, and the director of Cornell NeuroNex Hub, an NSF funded center for developing and disseminating neurotechnology. His current research areas are multiphoton microscopy for deep tissue imaging, multiphoton microendoscopy for clinical applications, and fiber-based devices and systems for optical imaging. Prior to Cornell, he was a member of technical staff at Bell Laboratories and pioneered breakthrough development of fiber optic communication systems based on differential phase-shift keying. He received his Ph.D. in Applied Physics, Cornell University. He has won the NSF CAREER award, Bell Labs team research award, the Tau Beta Pi Professor of the Year Award, and two teaching excellence awards from Cornell Engineering College. He received the 2017 Cornell Engineering Research Excellence Award. He is a member of the inaugural cohort of Ivy+ Provost Leadership Fellows in 2022. He is a fellow of the Optical Society of America, and a fellow of the National Academy of Inventors.