A Clinical Trial of SystemCHANGE to Improve Exercise, Diet and Health in HIV-Infected Adults
People living with HIV are at high risk for developing cardiovascular disease (CVD). Improving physical activity is an evidence-based strategy which when performed in a regular and sustained fashion, can help prevent and mitigate the severity of CVD. Yet, to achieve these benefits one must, over the long term, be physically active and regularly eat a health diet. An innovative approach to improving and maintaining health living behaviors such as physical activity and eating a healthy diet is the SystemCHANGE-HIV intervention. The BOBCAT Study aimed to:
- Evaluate the short-term and maintenance effects of SystemCHANGE-HIV on the amount and intensity of exercise
- To describe the impact of SystemCHANGE-HIV on cardiorespiratory fitness and cardiometabolic health
A two-group, randomized, repeated measures design was used to test the 3 and 6 month effects of SystemCHANGE-HIV. Participants were randomized to receive one of two conditions: (1) SystemCHANGE-HIV intervention, or (2) enhanced usual care. Subjects completed measures at baseline, 3, 6 (primary endpoints), 12, and 24 months. This study was registered at ClinicalTrials.gov #NCT02553291
This study is closed to new enrollment. All primary endpoints have been collected and are being analyzed.
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- Allison R. Webel, RN, PhD, FAAN, Frances Payne Bolton School of Nursing, Case Western Reserve University
- Rich Josephson, MAS, MD, Harrington Heart and Vascular Institute, Cleveland Medical Center
- Chris Longenecker, MD, Harrington Heart and Vascular Institute, Cleveland Medical Center
- Shirley M. Moore, PhD, RN, FAAN, Frances Payne Bolton School of Nursing, Case Western Reserve University
- Robert A. Salata, MD, University Hospitals Cleveland Medical Center
This project was funded by grants from the American Heart Association (14CRP20380259) and a developmental grant from the University Hospitals/Case Western Reserve University Center for AIDS Research (National Institutes of Health Grant # P30 AI036219) and as a pilot study from the SMART Center (National Institute of Nursing Research #P30NR015326).