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Human Stem Cell Research Oversight Committee (HSCRO)

Human Stem Cell Research Oversight Committee (HSCRO)

The Case Western Reserve University Human Stem Cell Oversight (HSCRO) Committee provides oversight of in vitro research involving:

  • the use of established human pluripotent stem cell lines that are limited to the National Institutes of Health (NIH) Human Pluripotent Stem Cell Registry;
  • the use of already existing human pluripotent stem cell lines;
  • the collection of tissues or embryos for derivation of new (not established or already existing) human pluripotent and induced pluripotent stem (hiPS) cell lines;
  • the procurement and use of IVF embryos for research, or the procurement and/or use of human gametes to create research embryos;
  • the in vitro culture of embryos or embryo-like structures;
  • the generation of human totipotent cells, and the mixing of totipotent or pluripotent stem cells with human embryos in vitro
  • the transfer of human unipotent or pluripotent stem cells, (hiPS) cells, and/or any of these stem cell types' direct derivatives into laboratory animals only where there is a possibility of human cell integration into the animals' central nervous systems (CNS) and/or the animals' sex cells.


CWRU HSCRO Application


Established cell lines
NIH Guidelines


International Society for Stem Cell Research
National Academy of Sciences


Colleen Karlo at or 216-368-0838
Kim Volarcik at or 216-368-0134