Human Stem Cell Research Oversight Committee (HSCRO)

The Case Western Reserve University Human Stem Cell Oversight (HSCRO) Committee provides oversight of in vitro research involving:

  • the use of established human pluripotent stem cell lines that are limited to the National Institutes of Health (NIH) Human Pluripotent Stem Cell Registry;
  • the use of already existing human pluripotent stem cell lines;
  • the collection of tissues or embryos for derivation of new (not established or already existing) human pluripotent and induced pluripotent stem (hiPS) cell lines;
  • the procurement and use of IVF embryos for research, or the procurement and/or use of human gametes to create research embryos;
  • the in vitro culture of embryos or embryo-like structures;
  • the generation of human totipotent cells, and the mixing of totipotent or pluripotent stem cells with human embryos in vitro
  • the transfer of human unipotent or pluripotent stem cells, (hiPS) cells, and/or any of these stem cell types' direct derivatives into laboratory animals only where there is a possibility of human cell integration into the animals' central nervous systems (CNS) and/or the animals' sex cells.


CWRU HSCRO Application

‌‌NIH Resources:

Established cell lines
NIH Guidelines

Other Resources:

International Society for Stem Cell Research
National Academy of Sciences

HSCRO Contacts:

Colleen Karlo at or 216-368-0838
Kim Volarcik at or 216-368-0134