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Human Research Protection Program (HRPP)

Human Research Protection Program (HRPP)

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Case Western Reserve University (CWRU) , MetroHealth, University Hospitals Case Medical Center (UHCMC), Cleveland Clinic (CCF) and the Louis Stokes Cleveland VA Medical Center (LSCVAMC) are all member institutions in the CWRU Human Research Protection Program.

Continuing Research Education Credit (CREC) Program

Case Western Reserve University's Continuing Research Education Credit (CREC) program provides investigators documented training in the protection of human subjects in research. The program is available to human subjects researchers at University Hospitals Case Medical Center, The MetroHealth System, CWRU, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, and The Cleveland Clinic.

All educational content is freely accessible to unaffiliated institutions and the general public.

CREC Program and Research Education

Conducting Research at Multiple Sites Under the CWRU HRPP

The Cleveland Area Reliant IRB Review process includes participation by the Case Western Reserve University (CWRU) Social, Behavioral, and Educational Research (SBER) IRB, the Cleveland Clinic (CCF) IRB, MetroHealth Medical Center (MHMC) IRB, and University Hospitals Case Medical Center (UHCMC) IRB. The process relies on executed IRB Authorization Agreements (IAA) between the institutions. These agreements document that all applicable human research subjects protection considerations will be made by one Institutional Review Board (IRB), which will be deemed the IRB of record. The IRBs of the other Cleveland area institutions will accept the approval of the IRB of record through the Reliant Review process. The goal is to eliminate duplication of effort and multiple applications for submission of the same protocol, and to encourage scientific collaboration among the affiliated institutions.

Cleveland Reliant Review Process

IRB Advisory Committee Governance

The IRB Advisory Committee (IAC) serves to provide centralized oversight of the CWRU HRPP and is overseen by CWRU's Vice President for Research. The IAC's core mission is to ensure that the oversight of human subject research is appropriate and in accordance with institutional, federal and state regulations under the CWRU HRPP. The secondary mission of the IAC is to share resources and best practices among member institutions and other institutions within our community to ensure the protection of participants in human research.

IRB Advisory Committee