National Institutes of Health (NIH) and Substance Abuse and Mental Health Services Administration (SAMHSA)

Other Deadline:

LOI due to Sponsor 11/11/2018, Full proposal due to Sponsor 12/11/2018

The National Institute on Drug Abuse (NIDA), in partnership with the Substance Abuse and Mental Health Services Administration (SAMHSA) is soliciting cooperative agreement applications with the intention of ultimately funding up to three research sites to participate in the 'HEALing Communities Study': Developing and Testing an Integrated Approach to Address the Opioid Crisis.  The HEALing Communities Study will test the immediate impact of implementing an integrated set of evidence-based interventions across healthcare, behavioral health, justice, and other community-based settings to prevent and treat opioid misuse and Opioid Use Disorders (OUD) within highly affected communities. Highly affected communities of interest are counties or cities within states that are burdened with higher than average rates of overdose mortality and opioid-related morbidity, and other complications.  Combined, all the communities participating in a single research site application must demonstrate having experienced at least 150 opioid related overdose fatalities (15% of these fatalities must be in rural communities) and a rate of 25 opioid related overdose fatalities per 100,000 persons or higher in the past year, based on the most recent complete year of data available. Communities within states ranking within the top third for age-adjusted drug overdose death rates in 2016, (per the Centers for Disease Control and Prevention) are of special interest.  The integrated set of evidence-based prevention and treatment interventions should be designed to achieve the following goals: reduce overdose fatalities (by 40% in a 3-year period), and events; decrease the incidence of OUD; and increase the number of individuals receiving medication to treat OUD, retained in treatment beyond 6 months, and receiving recovery support services, and the distribution of naloxone compared to baseline.

Number of Applications
Amount of Funding

Application budgets need to reflect the actual needs of the proposed project.

NIDA intends to commit up to $89.5M in FY 2019, $96.5M in FY 2020 and 2021, and $48.5M in FY 2022 to fund up to 3 Research Sites, subject to availability of funds. The maximum project period is 4 years.


The PD/PI of the research site application must commit a minimum of 5 person-months annually over the life of the grant award.   

Submission Process

Step 1

A single pdf file letter of intent no longer than two (2) pages must be submitted to Stephanie Endy ( by 5pm on October 29, 2018.  The file must include the following information:

  • Number and title of this funding opportunity

  • Descriptive title of proposed activity
    Name(s), address(es), and telephone number(s) of the PD(s)/PI(s)

  • Names of other key personnel; name and title of governmental official serving as key personnel

  • Participating institution(s); participating communities; participating community-based organizations

  • A description of the proposed project.

Step 2

Final nominees will be notified of their selection by October 31, 2018

Step 3

LOI must be received by the Office of Research Administration by November 5, 2018 at 5:00pm EST.

Step 4

LOI must be received by the sponsor by November 11, 2018 at 5:00pm EST.

Step 5

Final proposal must be received by the Office of Research Administration by December 4, 2018 at 5:00pm EST.

Step 6

Final proposal must be received by the sponsor by December 11, 2018 at 5:00pm EST.


Abstract or LOI to ORA Chosen Proposal Announced ORA Final Proposal Due Date Sponsor Submission Deadline Days Until Due
10/29/2018 10/31/2018 11/05/2018 11/11/2018 CLOSED