Collaborative Program Grant for Multidisciplinary Teams (RM1)

This funding opportunity announcement (FOA) is designed to support highly integrated research teams of three to six PD/PIs to address ambitious and challenging research questions that are important for the mission of NIGMS and are beyond the scope of one or two investigators. Collaborative program teams are expected to accomplish goals that require considerable synergy and managed team interactions. Project goals should not be achievable with a collection of individual efforts or projects. Teams are encouraged to consider far-reaching objectives that will produce major advances in their fields.

Proposal Considerations:

NIGMS has only funded 3 awards under this program announcement; applicants are strongly encouraged to review these funded applications in NIH RePORTER before speaking with a program officer to ascertain the appropriateness of their intended topic.  An overview of NIGMS and their areas of interest are available online in the program announcement.

Applications that are mainly focused on the creation, expansion, and/or maintenance of community resources, creation of new technologies or infrastructure development are not appropriate for this FOA.

NIGMS intends to fund a limited number of applications. Therefore, consultation with relevant staff at least 10 weeks prior to the application due date is strongly encouraged. Once applicants have identified overall program objectives and PD/PI participants, NIGMS staff may be able to advise applicants whether the proposed research strategy meets the goals and mission of the Institute, whether it addresses one or more high priority research areas, and whether it is appropriate for a collaborative team program. During the consultation phase, if the proposed research strategy does not meet NIGMS' programmatic needs or is not appropriate as a Collaborative Program Grant, applicants will be encouraged to consider other funding opportunities.

A collaborative program that is closely related to the goal of a PD/PIs' existing NIGMS-funded research might require that funding be relinquished to avoid overlap.

Applications should be sufficiently challenging, ambitious, and innovative that the proposed research cannot be achieved by a single investigator or small group of investigators.

A multiple PD/PI application is required and applications must include a minimum of three and a maximum of six PD/PIs who are all necessary to provide sufficient research capacity and the relevant expertise to address the proposed scientific problem. 

The contact PD/PI is required to devote at least 30% of his/her time available for research to this award, while other PD/PIs are required to devote at least 25% of his/her time available for research to this award.

Number of Applications
Amount of Funding

While applications may request research program budgets of up to $1.5 million direct costs per year, it is anticipated  that most awards will be between $700,000-$900,000 direct costs. Inflationary adjustments are not allowed. The requested budget should be consistent with the number of PDs/PIs and the complexity and needs of the proposed program. In addition to the research program budget, an additional $250,000 direct costs per year may be requested for optional exploratory pilot studies for ESIs.


Submission Process

Step One

For consideration as a finalist, investigators should submit the following materials as a single PDF e-mail attachment to no later than 5:00 p.m. on September 17, 2019:

    • A one-page cover letter including the title of the project, a list of all the PIs, their departments and institutions, identification of the contact PI, their department and school, and a paragraph describing how the project is aligned to a specific NIGMS priority.  This last paragraph on how the project is aligned to a specific NIGMS  priority should include information learned from a conversation with the appropriate NIGMS program officer who encouraged the team to move forward with an application.
    • A one-page description of the project that demonstrates the synergy between the areas of expertise brought by each PI, the objectives of the project, and how the objectives will produce major advances in their fields.
    • NIH style biosketches for each of the PIs.
    Step Two

    Nominees will be notified by September 30, 2019.

    Step Three

    The final proposal must be received by the Office of Research Administration or the SOM Office of Grants and Contracts by January 20, 2020

    Step Four

    The final proposal is due to NIH by 5pm on January 25, 2020.


    Abstract or LOI to ORA Chosen Proposal Announced ORA Final Proposal Due Date Sponsor Submission Deadline Days Until Due
    09/17/2019 09/30/2019 01/20/2020 01/25/2020 CLOSED