Warren J. Rice Colloquium Series Fall 2016 - Down Syndrome and Dementia: Using Imaging Measures to Characterize and Track Disease Progression

December 2, 2016, 2:00pm – 3:30pm

Mather Memorial, Room 201
1.5 PD Hours

Dr. Katherine Koenig, Ph.D.
Assistant Professor, Radiology
Cleveland Clinic Lerner College of Medicine

Individuals with Down syndrome (DS) develop Alzheimer-type dementia earlier and more often than the general population, with over half showing symptoms of dementia by age 60. Variations in baseline cognitive level and a lack of information on healthy aging in DS complicate the diagnosis of dementia. My research focuses on the development of MRI-based biomarkers to predict dementia onset or track dementia progression. Using structural and functional MRI measures, tests of cognitive function and dementia symptoms, and measures of amyloid and dementia-related genetic markers, I hope to untangle the relationship of brain changes associated with aging, baseline cognitive level, and dementia onset in those with DS.