Case Western Reserve University Tuberculosis Research Unit
  Integrating research to combat the global TB epidemic

TBRU Sponsor Information

National Institute of Allergy and Infectious Diseases, Division of Microbiology and Infectious Diseases

The National Institute of Allergy and Infectious Diseases (NIAID), Division of Microbiology, and Infectious Diseases (DMID) established the Tuberculosis Research Unit (TBRU) through a contract (N01-AI-45244) with Case Western University in 1994. This contract was renewed for seven years in 1999 (N01-AI-95383) and for an additional seven years in 2007 (N01-AI-70022).

The purpose of this contract is to create a multidisciplinary, international team, dedicated to:

  • Identifying and validating surrogate markers of Mycobacterium tuberculosis (Mtb) infection and tuberculosis (TB) disease progression
  • Identifying the correlates of the human protective immune response to Mtb infection
  • Providing a collaborative infrastructure for clinical research and early stage clinical trials for drugs, vaccines and diagnostics for TB

The TBRU represents a cornerstone in the NIAID's contribution to the global fight against tuberculosis. Since the resurgence of TB in the United States during the early 1990's, the NIAID has increased its funding for TB research — from $3 million to $56 million in 2001 — which helped to establish a solid research infrastructure for TB. The TBRU contract and is designed to support translation of basic research findings into tools and approaches needed for the development of better drugs, vaccines, and diagnostics, to improve clinical trials and for advancing health care interventions in TB endemic countries.


Christine F. Sizemore, Ph.D.
Tuberculosis Chief, TB, Leprosy and other Mycobacterial Diseases Section
Division of Microbiology and Infectious Diseases
610 Rockledge Dr., Room 3313
Bethesda, MD 20892
Phone: 301-496-5305 (direct: 301-435-2857)
FAX: 301-496-8030