Case Western Reserve University Tuberculosis Research Unit
  Integrating research to combat the global TB epidemic

Highlights from Completed Research Studies

The TBRU has completed numerous clinical trials, epidemiologic and observational studies as well as smaller developmental projects all focused on addressing important questions, issues and controversies in the human response to M. tuberculosis exposure, infection and disease.  Our findings have largely been reported in the literature although a number of follow-up activities and completion studies have carried over or are being extended into current studies. See specific highlights from our completed research:

Current Research Questions

The TBRU designs and conducts multi-disciplinary clinical studies of M. tuberculosis infection and disease, that address critical questions on the path towards new preventive, diagnostic, and therapeutic strategies for TB. The TBRU's Scientific Working Groups oversee study design and scientific priorities. Scientific priorities and studies are formulated in response to the NIH/NIAID\x92s Statement of Work. Research questions, as well as links to current TBRU research studies designed to address these questions, are detailed in the Table of Research Questions.

Current Research Structure

The TBRU functions as a multi-disciplinary, multi-national consortium of investigators and institutions in the United States, Europe and Africa, and is based and coordinated at Case Western Reserve University. The TBRU's aims and studies are focused around NIH/NIAID\x92s Statement of Work. The TBRU brings together the expertise of microbiologists, immunologists, human geneticists, epidemiologists and experts in clinical trials for its studies. Descriptions of TBRU\x92s research structure and work at current field and laboratory sites are described in more detail in Research Structure.

Study Descriptions

The TBRU has and continues to conduct numerous cohort studies and clinical trials involving adult and pediatric persons with M. tuberculosis infection and disease. Click on the links below for more information on specific completed and ongoing studies.