Case Western Reserve University Tuberculosis Research Unit
  Integrating research to combat the global TB epidemic
Study Period

Kawempe Community Health Study

(DMID Protocol Number: 01-005)

Type of Study

Observational Household Contact Study


Hybrid Cross-sectional / Cohort

Project Site

Kawempe Division and adjacent parishes in Kampala, Uganda

Sample Size

150 subjects with clinically active tuberculosis per year and their households


Adults with a culture confirmed, initial case of clinically active tuberculosis and members of their households with active TB, TB infection, and exposure but no infection

First degree relatives of adults with a culture confirmed, initial case of clinically active tuberculosis

Study Period


Goal of Study:

An overarching goal of the TBRU is to develop and implement a systematic and multidisciplinary approach towards furthering scientific understanding of the epidemiology, microbiology, immunology and host genetics of MTB infection and disease in populations with a high prevalence of disease. The Household Contact Study provides a framework for assessing the risk of infection with MTB and of developing active TB, for evaluating innovative methods for prevention, diagnosis and treatment, and for assessing the burden of disease in a community with a high prevalence of TB.

Objectives of Study:
  1. To determine critical host factors associated with primary MTB infection, re-infection, reactivation, and progression of clinical disease
  2. To identify and track individual strains of MTB through Ugandan households and local community
Research Activities: