Case Western Reserve University




James W. Jacobberger


Mammalian cell biology and cancer cell biology

Office Phone: 216-368-4645


B.S. - Microbiology, University of Nebraska, 1976;
Ph.D. - Microbiology and Immunology, University of Rochester, 1983;
Post-doctoral fellowship - Experimental Pathology, University of Colorado Health Sciences Center, 1983-85

Primary Appointment: Case Comprehensive Cancer Center

I am interested in cell biology, cancer cell biology, oncogenesis, "biomarkers", and mathematical modeling of cell process regulation.  Early work in the lab focused on cell immortalization through expression of SV40 large T antigen and development of cytometric methods to analyze the cell cycle.  Our present interests focus on analysis of cell signaling and the cell cycle by cell-based methodology, and mathematical modeling of the cell cycle and cell signaling.  The latter is in collaboration with Sree Sreenath (Computer Sciences and Electrical Engineering) and Tom Radivoyevitch (Epidemiology and Biostatistics).

We have two main enterprises in the lab: "multi-variate cell cycle analysis and modeling" and "measurement and analysis of cell signaling as a leukemia biomarker". There is a single overarching goal – to test the following set of ideas within the context of human disease: (1) multi-variate cytometric data, measuring key process-related epitopes, resolve to kinetic profiles of programmed gene expression, and (2) a series of bivariate views or a single N-dimensional view of these profiles produce quantifiable/ classifiable discrete cell states that monitor cell processes (e.g., mitosis).

The long range goal is to create an analytical system, preferably within a clinical pathology or observational basic cell biology modes of investigation, in which the measurements are interactively interrogated by the investigator and a computer program with mathematical models of cell biochemistry and integrated systems simulations running underneath.


Selected Publications

Frisa PS, Jacobberger JW (2010) Cytometry of chromatin bound Mcm6 and PCNA identifies two states in G1 that are separated functionally by the G1 restriction point. Bmc Cell Biology 11: 26. [PubMed]

van Boxel-Dezaire AH, Zula JA, Xu Y, Ransohoff RM, Jacobberger JW, et al. (2010) Major Differences in the Responses of Primary Human Leukocyte Subsets to IFN-{beta}. J Immunol. [PubMed]

Kunos CA, Radivoyevitch T, Pink J, Chiu SM, Stefan T, et al. (2010) Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers. Radiat Res 174: 574-581.

Frisa PS, Jacobberger JW (2009) Cell Cycle-Related Cyclin B1 Quantification. Plos One 4: e7064.. [PubMed]

Jacobberger JW, Frisa PS, Sramkoski M, Stefan T, Shults KE, et al. (2008) A new biomarker for mitotic cells. Cytometry Part A 73A: 5-15. [PubMed]

Complete list of Publications