Case Western Reserve University




Michael M. Lederman

Scott R Inkley Professor of Medicine
Co-Director, CWRU/UHC Center for AIDS Research
Principal Investigator, CWRU/UHC AIDS Clinical Trials Unit

Mechanisms of immune deficiency, Enhancing immune function in HIV-1 infection

Office Phone: 216-844-3979


Dr. Lederman has served as intern, resident, chief resident in Medicine and fellow in Infectious Diseases at Case Western Reserve University where he joined the faculty in 1980. He is a member of the American Association of Immunologists, the Infectious Diseases Society of America, the HIV Medicine Association and is a councilor of the Clinical Immunology Society. He is on the editorial boards of AIDS, the Journal of AIDS and Clinical Immunology.


Selected Publications

Lederman MM, Veazey R, Hartley O, Mosier D, Dufour J, Mefford M, Piatak M Jr. Salkowitz JR, Rodriguez B, Blauvelt A, Offord R. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science 306:485-7, 2004. [PubMed]

Salkowitz JR, Sieg SF, Harding CV, Lederman MM. In vitro human memory CD8 T cell expansion in response to cytomegalovirus requires CD4+ T cell help. J Inf Dis 204:971-83, 2004. [PubMed]

Lange CG, Lederman MM, Medvik K, et al. Nadir CD4+ T-cell count and numbers of CD28+ CD4+ T-cells predict functional responses to immunizations in chronic HIV-1 infection. Aids. Sep 26 2003;17(14):2015-2023. [PubMed]

Quinones-Mateu ME, Lederman MM, Feng Z, et al. Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication. Aids. Nov 7 2003;17(16):F39-48. [PubMed]

Sieg SF, Bazdar DA, Lederman MM. Impaired TCR-mediated induction of Ki67 by naive CD4+ T cells is only occasionally corrected by exogenous IL-2 in HIV-1 infection. J Immunol. Nov 15 2003;171(10):5208-5214. [PubMed]

Complete list of Publications