Tadao Maeda, M.D., Ph.D.
Case Western Reserve University
Department of Ophthalmology and Visual Sciences
2085 Adelbert Road, Institute of Pathology, Rm 115
Cleveland, Ohio 44106
Phone: (216) 368-6103 Fax: (216) 368-3171
Research Focus: Cone function
Human vision starts photon absorption of visual pigments in two kinds of photoreceptor cells, cone photoreceptor cell and rod photoreceptor cell. The cone cells are localized in the macula and provide color vision in daytime whereas rod cells are localized outside of macular lesion and cover entire retina to work for dark-vision which is percept as monoclomatic vision. To maintain human vision, the visual pigments must be regenerated with visual chromophore, 11-cis-retinal, via retinoid cycle which is sequential enzymatic reactions occurring between photoreceptor cells and retinal pigmented epithelial cell (RPE). Of importance, it is known that loss or abnormality of particular enzymes of the visual cycle causes certain retinal diseases, such as Retinitis Pigmentosa, Leber congenital amaurosis, Stargardt’s disease and age-related macular degeneration (AMD).
The major research interest of Dr. Tadao Maeda is to elucidate pathological roles of cone and rod cells in these diseases. To persue these researches, Dr Maeda study animal models which are genetically modified to have retinal diseases like as human patients and enable us to study cone and rod cell function independently by using various advanced imaging techniques. Dr. Maeda is exploring the new genes which may be responsible for the common pathway of various retinal degenerations by using quite unique genetic tools, chromosome substation strain as well. Based on these significant research outcomes, Dr. Maeda is developing the pharmacological and genetic therapies in collaboration with Dr. Palczewski Lab, Department of Pharmacology, Case Western Reserve University.
Lab Openings: A postdoctoral position is available to study retinal diseases using mouse models. We are seeking an energetic, highly motivated PhD, MD, or MD/PhD with solid publication record and experience in ophthalmic examinations, biochemistry, immunology, genetics, or neuroscience.