Eye Image Reading Centers

The Eye Image Reading Centers mission is to provide superior image analysis and trial development support for clinical trials and studies examining the effects of drugs, devices, and diseases on the cornea and the retina

The Image Reading Centers at University Hospitals Eye Institute and Case Western Reserve University is comprised of two of the leading ophthalmic image analysis centers:

Cornea Image Analysis Reading Center

Retina Diseases Image Analysis Reading Center

Established at University Hospitals Case Medical Center and Case Western Reserve University, the two reading centers have extensive experience with multicenter, national and international, federal and corporate-sponsored clinical trials. Our standardized protocols ensure rapid and consistent analyses, while our technical expertise results in refined acquisition, training and analysis techniques. This technical expertise is enhanced by significant medical director involvement in study design to ensure the highest quality and limit inconsistencies.

Image Reading Centers are governed by the University Hospitals Institutional Review Board, which is fully accredited by the Association for the Accreditation of Human Research Protection Programs. Our staff follows the regulations set forth by Good Clinical Practices, International Conference on Harmonization, Department of Health and Human Services, and Food and Drug Administration regulations.

Our work with nationally recognized principal investigators, contract research organizations, federal agencies and large pharmaceuticals allows us to tailor our analyses toward improved anatomic and body composition data while maintaining scientific integrity.

We provide image analysis for a variety of ophthalmic diseases, including Fuchs' dystrophy, diabetic macular edema, neovascular and non-neovascular macular degeneration, vitreoretinal interface disorders, neuro-ophthalmological diseases, uveitis and glaucoma. We also evaluate corneal endothelial safety and toxicity related to devices in the anterior chamber, corneal and intraocular surgery and viscoelastics; and retinal safety related to intravitreal medications. Additionally, the center grades ocular images for safety studies of drugs used in nonophthalmological studies.

We offer a full array of grading and analysis services for both the cornea and retina, including corneal endothelial cell density, coefficient of variation, percent of hexagonal cells, epithelial staining analysis, analysis of confocal images of the epithelium and stroma, fundus photography and fluorescein angiography.

Please click the links above to access the web pages for each of our two reading centers.

University Hospitals Case Medical Center is the primary affiliate of Case Western Reserve University School of Medicine, a national leader in medical research and education and consistently ranked among the top research medical schools in the country by U.S.News & World Report. Through their faculty appointments at Case Western Reserve University School of Medicine, physicians at UH Case Medical Center advance medical care through innovative research and discovery that bring the latest treatment options to patients.

For more information on the Image Reading Centers or if you have questions, please contact one of the following:

Jonathan Lass, MD, Medical Director, Cornea Image Analysis Reading Center
Charles I Thomas Professor, Department of Ophthalmology & Visual Sciences
Case Western Reserve University School of Medicine
Ph: 216-844-8590

Beth Ann Benetz, CRA, FOPS Technical Director, Image Reading Centers Retinal Diseases
Director, Retinal Image Analysis Reading Center
Professor, Case Western Reserve University School of Medicine
Ph: 216-844-3615

Nicola Goodall, MSW Project Manager, Image Reading Centers

Please note our new location:

Eye Image Reading Centers
Midtown Tech Park
6700 Euclid Avenue, STE 103
Cleveland, Ohio 44103