Thursday, October 17
4:30 Brian Kobilka – Stanford University (Keynote Lecture)
"Structural insights into G protein coupled receptor signaling"
Welcome Reception and Poster Session 1 (odd numbered posters)
Friday, October 18
Symposium 1: Hubert Van Tol Symposium on animal models
Krzysztof Palczewski – Case Western Reserve University
"Genetic approaches to understand oligomerizations of GPCRs"
Morley Hollenberg – University of Calgary
"Proteinase-stimulated signaling in vitro & in vivo: a GPCR-enzyme Partnership"
Katherine Lee - University of Western Ontario
"Protective effect of the RGS2-eIF2B binding domain (RGS2eb) against pathological cardiac hypertrophy"
Walter Koch – Temple University
"GRK2 Inhibition in the Failing Heart - Nearing Translation"
10:00 Coffee Break
Symposium 2: GPCR Signaling in Vision
Vsevolod V. Gurevich – Vanderbilt University
"Targeted design of signaling-biased arrestins"
Michael Cheetham - UCL Institute of Ophthalmology, UK
"Molecular chaperones in the biogenesis and quality control of rhodopsin"
Beata Jestrzebska - Case Western Reserve University
"Supramolecular architecture of the rhodopsin-transducin complex"
Symposium 3: Biophysical Studies of GPCRs
Reinhard Grisshammer – National Institutes of Health
"Structure of the agonist-bound neurotensin receptor NTS1"
Scott Prosser – University of Toronto
"Understanding the role of Ligands on GPCR Activation by NMR"
Shanna Bowersox - Carnegie Mellon University
"Cell-autonomous tuning of opioid sensitization by substance P"
Rabindra Shivnaraine - University of Toronto
"Probing the receptor-G protein interaction in live cells using dual-color fluorescence correlation spectroscopy (DCFCS) and Forster resonance energy transfer (FRET)"
Stanley Opella – University of California, San Diego
"Structure, dynamics, and function of unmodified GPCRs in phosopholipid bilayers under physiological conditions"
3:00 Coffee Break
Symposium 4: Translational GPCR Research
Rick Neubig - Michigan State University
"Attacking challenging drug targets: gene transcription downstream of GPCRs"
Derek Leishman - Eli Lilly
"Early safety assessment: when and how much"
Thomas Facklam - BioMotiv
"From hit to the Clinic"
Panel Discussion-Translating Biology to Therapeutics
Poster Session 2 with Reception Dinner (even numbered posters present)
9:00 Board Meeting (to discuss next retreat) all PIs welcome
Saturday, October 19
Symposium 5: Non-Canonical GPCR Signaling
Xiaoping Du – University of Illinois, Chicago
"Crosstalk between GPCR and integrins"
Jean-Pierre Vilardaga – University of Pittsburgh
"Noncanonical GPCR signaling mechanisms"
Stéphanie Clément - McGill University
"Biased signaling and allosteric moculation of the Angiotensin II type 1 receptor"
Jonathan Stamler - Case Western Reserve University
"Signaling through GPCRs by S-nitrosylation"
10:00 Coffee Break
Symposium 6: GPCR Action Inside the Cell
JoAnn Trejo – University of California, San Diego
"Ubiquitin and Intracellular Signaling by GPCRs"
Bruce Allen – Universite de Montreal/Montreal Heart Institute
"Intracrine GPCR signalling in the adult cardiomyocyte"
Jean Luc Parent – University of Sherbrooke
"Functional cooperativity from an interaction between a GPCR and the intracellular synthase of its agonist"
Nevin Lambert – Georgia Health Science University
"Movement of Gs between plasma membrane receptors and intracellular compartments"
Poster Awards and Closing Remarks - Marvin Nieman (Organizing Committee)
12:15 Lunch and Depart