Bioinformatics/Biostatistics Core (pilot)


The Department of Ophthalmology & Visual Sciences is piloting a new core called the Vision Biostatistics and Bioinformatics Core (VBBC). The goals of this core are:

1) To provide NEI R01 holders the expertise and centralized access to all biostatistical and bioinformatics resources at Case

2) To educate eye researchers about available genomic resources for vision and foster new collaborations

3) To support the submission of the new NEI R01 grants with a strong biostatistics/bioinformatics component.

Specifically, the VBBCS will provide professional consultation on: (a) Design of research studies, (b) Statistical analysis and interpretation of data, (c) Sample size calculation and power analysis, (d) Designing data collection systems and instruments, (e ) Data entry, data management, and quality assurance, (f) Gene expression profiling (e.g. RNA Seq or Trancriptomics), (g) Whole genome or whole exome sequencing, (h) Microbiome analysis, (i) Pathway analysis (e.g. IPA analysis), (j) look-ups for SNPs for GWAS results in the UCSC browser and the GTeX database, (k) Other ‘Omic Projects on a case by case basis, (l) Creation of scientific reports, tables, figures for papers, professional meetings and grants.

The current tentative fee for the VBBCS services is $140/hour and we are testing the following financial arrangements.

Existing NEI R01 grants with limited Biostatistics or Bioinformatic support. The VSRC will issue a voucher for 50% of 10 hours of work per grant. The other 50% will be charged to the Principal Investigator’s NEI grant. Extensions beyond the 10 hour window will be charged to the Principal Investigator’s NEI grant. All charges will be billed monthly.

Pre-proposal development for NEI R01 funding. The VSRC will issue vouchers for 5 hours per user for development of a statistical or bioinformatics analysis plan and power calculations for a new (or resubmission of NEI R01 grant proposals. Generation of a small amount of preliminary data can also be included in this plan to a maximum of an additional 5 hours per user. The maximum charges will be 20 hours per proposal, for example, 10 hours for biostatistics, and 10 hours for bioinformatics. Each investigator may request vouchers for 20 hours annually, not 20 hours for each R01 grant submitted.

Sudha Iyengar, Ph.D., Module Director
Department of Epidemiology and Biostatistics
Wolstein Research Building Room 1315
Phone: (216) 368-4388
sudha.iyengar@case.edu