Clifford V. Harding, M.D., Ph.D.Kahn Professor, Chair
ITP Director, MSTP Director
2103 Cornell Rd.
Cleveland, OH 44106-7288
phone: (216) 368-3611
fax: (216) 368-1539
Dr. Harding graduated magna cum laude and with Highest Honors in Biology from Harvard College in 1979. He completed his M.D. and Ph.D. in Cell Biology at Washington University of St. Louis in 1985. He served as Resident in Pathology, Chief Resident in Pathology, Instructor in Pathology and Assistant Professor of Pathology at Washington University. Since 1993 he has been a faculty member at CWRU/University Hospitals Case Medical Center. He is currently the Joseph R. Kahn Professor and Chair of Pathology, Director of the Medical Scientist Training Program, and Interim Chair of Anatomy.
Dr. Harding has a long-standing NIH-funded research program on the cell biology of antigen presenting cells (APCs) and their regulation by Toll-like receptors (TLRs) or infection with Mycobacterium tuberculosis (Mtb) or HIV. He has over 190 publications on topics in immunology, cell biology and infectious diseases (>10,500 citations, h-index = 55). His early work included the discovery of exosomes and their genesis by exocytosis of multivesicular exosomes in 1983, and participation in the first study demonstrating that exosomes from APCs contain MHC molecules (1996). In recent years he has published on exosomes released from macrophages, including exosomes from Mtb-infected macrophages that bear bacterial molecules. His work from the 1980’s and 1990’s included fundamental discoveries concerning cell biological and biochemical mechanisms of antigen processing and antigen presentation by MHC-I and MHC-II molecules. His recent research has studied the regulation of APCs, particularly in the context of infection and signaling by innate immune receptors. He has studied the regulation of APCs by TLR2 agonists expressed by Mtb (lipoproteins and glycolipids) and the signaling pathways by which Mtb regulates the balance of inflammatory mechanisms in macrophages and the magnitude and differentiation of T cell responses. These mechanisms may contribute to immune evasion and the persistence of Mtb infection. Other projects have focused on regulation of immune responses by TLR9 and type I interferon.
Please see the links below for more information pertaining to Dr. Harding's research, publications, and training.