Welcome to the Xinglong Wang Laboratory of Neurodegeneration
Alzheimer’s disease (AD) is the most prevalent form of dementia characterized by neuronal loss in the neocortex and hippocampus. Parkinson’s disease (PD) is the second most common cause of dementia characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. Frontotemporal dementia (FTD) is the second most common form of early-onset dementia caused by neuronal loss in the frontal and temporal cortex. Amyotrophic lateral sclerosis (ALS) is the most common motor disease characterized by progressive motor neuron degeneration in brain stem and spinal cord. My research interest is to understand the mechanism(s) underlying neuronal death in various major neurodegenerative diseases with a focus on AD, PD, FTD and ALS.