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Basch Lab

Basch Lab

Basch Lab

The compsite banner shows a variety of images from the Basch lab, including fluorescent immunostaining and in situ hybridizations of the inner ear.
About Us
Our research is focused in understanding and preventing the causes of congenital deafness and age-related hearing loss.

In the United States, about two to three out of every 1,000 children are born with a detectable level of hearing loss in one or both ears. Of the approximately 37.5 million Americans aged 18 and over who report some trouble hearing, nearly 33 percent are aged 65-74, and 50 percent are 75 and older with disabling hearing loss.

We use the mouse embryo as a model system to understand how the inner ear forms. We study how the different cell types in the cochlea interact with each other during embryonic development. Our goal is to apply the lessons learned from normal development towards regenerative therapies in cases of congenital deafness and age-related hearing loss.

Section through a transgenic cochlea showing genetically labeled intermediate cells in the stria vascularis.

Our Research

We are dedicated to understanding the normal and pathological development of the stria vascularis, and its implications in congenital and age related hearing loss.
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Schematic of the experimental design for isolation of strial cells.

Our Protocols

We offer a list of the most commonly used technical protocols in the Basch Lab.
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