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Pathology

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Publications

Publications

For the most recent list on Pubmed, click  here.

Jun, J.C., Jones, M.B., Oswald, D.M., Sim, E.S., Jonnalagadda, A.R., Kreisman, L.S.C., Cobb, B.A. (2017) “T cell-intrinsic TLR2 stimulation promotes IL-10 expression and suppressive activity by CD45RbHi T cells”, PLoS One 12(7): e0180688. [Pubmed]

Baum, L.G., Cobb, B.A. (2017) “The direct and indirect effects of glycans on immune function”, Glycobiology 27(7), pp. 619-624. [Pubmed]

Jones, M.B., Oswald, D.M., Joshi, S., Whiteheart, S.W., Orlando, R., Cobb, B.A. (2016) “B cell Independent Sialylation of IgG”, Proceedings of the National Academy of Sciences 113(26), pp. 7207-7212. [Pubmed]

Jones, M.B., Ryan, S.O., Johnson, J.L., Cobb, B.A. (2016) “Dendritic Cell-Specific Mgat2 Knockout Mice Show Antigen Presentation Defects but Reveal an Unexpected CD11c Expression Pattern”, Glycobiology 26(9), pp. 1007-1013. [Pubmed]

Johnson, J.L., Jones, M.B., Cobb, B.A. (2015) "Polysaccharide A from the capsule of Bacteroides fragilis induces clonal CD4+ T cell expansion", Journal of Biological Chemistry 290(8), pp. 5007-5014. [Pubmed]

Johnson, J.L., Jones, M.B., Cobb, B.A. (2015) "Bacterial capsular polysaccharide prevents the onset of asthma through T cell activation", Glycobiology 25(4), pp. 368-375. [Pubmed]

Ryan, S.O., Abbott, D.W., Cobb, B.A. (2014) "Myeloid glycosylation defects lead to a spontaneous common variable immunodeficiency-like condition with associated hemolytic anemia and antilymphocyte autoimmunity", Journal of Immunology 192(12), pp. 5561-5570. [Pubmed]

Cobb, B.A. (2014) "Is donor glycosylation the gatekeeper for xenotransplantation?" American Journal of Transplantation 14(4), pp. 745-747. [Pubmed]

Taylor, P.R., Roy, S., Leal Jr., S.M., Sun, Y., Howell, S.J., Cobb, B.A., Li, X., Pearlman, E. (2014) "Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgt and Dectin-2", Nature Immunology 15(2), pp. 143-151. [Pubmed]

Ryan, S.O., Leal Jr., S.M., Abbott, D.W., Pearlman, E., Cobb, B.A. (2014) "Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses", Glycobiology 24(3), pp. 262-271. [Pubmed]

Jun, J.C., Kertesy, S., Jones, M.B., Marinis, J.M., Cobb, B.A., Tigno-Aranjuez, J.T., Abbott, D.W. (2013) "Innate immune-directed NF-kB signaling requires site-specific NEMO ubiquitination", Cell Reports 4(2), pp. 352-361. [Pubmed]

Bloem, K., Garcia-Vallejo, J.J., Vuist, I.M., Cobb, B.A., van Vliet, S.J., van Kooyk, Y. (2013) "Interaction of the Capsular Polysaccharide A from Bacteroides fragilis with DC-SIGN on Human Dendritic Cells is Necessary for Its Processing and Presentation to T cells", Frontiers in Immunology 4(Article 103). [Pubmed]

Ryan, S.O., Johnson, J.L., Cobb, B.A. (2013) "Neutrophils Confer T cell Resistance to Myeloid-Derived Suppressor Cell-Mediated Suppression to Promote Chronic Inflammation", Journal of Immunology 190(10), pp. 5037-5047. [Pubmed]

Johnson, J.L., Jones, M.B., Ryan, S.O., Cobb, B.A. (2013) "The Regulatory Power of Glycans and their Binding Partners in Immunity", Trends in Immunology 34(6), pp. 290-308. [Pubmed]

Xiao, X., Yuan, J., Haik, S., Cali, I., Zhan, Y., Li, B., Moudjou, M., Laplanche, J-L., Laude, H., Langeveld, J., Gambetti, P., Kitamoto, T., Kong, Q., Cobb, B.A., Brandel, J-P., Petersen, R.B., Zou, W-Q. (2013) "Glycoform-Selective Prion Formation in Sporadic and Familial Forms of Prion Disease", PLOS One 8(3): e58786. [Pubmed]

Leal Jr., S.M., Vareechon, C., Cowden, S., Cobb, B.A., Latge, J-P., Momany, M., Pearlman, E. (2012) "Fungal Antioxidant Pathways Promote Survival Against Neutophils During Infection", Journal of Clinical Investigation 122(7), pp. 2482-2498. [Pubmed]

Taylor, C.E., Cobb, B.A., Rittenhouse-Olson, K., Paulson, J., Schreiber, J.R. (2012) "Carbohydrate Moieties as Vaccine Candidates: Targeting the Sweet Spot in the Immune Response", Vaccine 30(30), pp. 4409-4413. [Pubmed]

Marinis, J.M., Hutti, J.E., Homer, C.R., Cobb, B.A., Cantley, L.C., McDonald, C., Abbott, D.W. (2012) "IkB Kinase alpha Phosphorylation of TRAF4 Down-Regulates Innate Immune Signaling", Molecular Cell Biology 32(13), pp. 2479-2489. [Pubmed]

Ryan, S.O. and Cobb, B.A. (2012) "Roles for Major Histocompatibility Complex Glycosylation in Immune Function", Seminars in Immunopathology special volume on Glycosylation and Immunity 34(3), pp. 425-441. [Pubmed]

Rabinovich, G.A., van Kooyk, Y., Cobb, B.A. (2012) "Glycobiology of immune responses", Annals of the New York Academy of Sciences 1253(1), pp. 1-15. [Pubmed]

Ryan, S.O. and Cobb, B.A. (2012) "Host Glycans and Antigen Presentation", Microbes and Infection 14, pp. 894-903. [Pubmed]

Kreisman, L.S.C. and Cobb, B.A. (2012) "Infection, Inflammation, and Host Carbohydrates: A Glyco-Evasion Hypothesis", Glycobiology 22(8), pp. 1019-1030. [Pubmed]

Lewis, C.J. and Cobb, B.A. (2011) "Adaptive Immune Defects Against Glycoantigens in Chronic Granulomatous Disease via Dysregulated Nitric Oxide Production", European Journal of Immunology 41(9), pp. 2562-2572. [Pubmed]

Cobb, B.A., Rabinovich, G.A., van Kooyk, Y. (2011) "State of the Union: Glycobiology and Immunology in the Canadian Rockies", Glycobiology 21(5), pp. 545-546. [Pubmed]

Young, N.M., Kreisman, L.S.C., Stupak, J., Maclean, L.L., Cobb, B.A., Richards, J.C. (2011) "Structural characterization and MHCII-dependent immunological properties of the zwitterionic O-chain antigen of Morganella morganii", Glycobiology 21(10), pp. 1266-1276. [Pubmed]

Ryan, S.O., Bonomo, J.A., Zhao, F., Cobb, B.A. (2011) "MHCII Glycosylation Modulates Bacteroides fragilis Carbohydrate Antigen Presentation", Journal of Experimental Medicine 208(5), pp. 1041-1053. [Pubmed]

Kreisman, L.S.C. and Cobb, B.A. (2011) "Glycoantigens Induce Human Peripheral Tr1 Cell Differentiation with Gut-homing Specialization", Journal of Biological Chemistry 286(11), pp. 8810-8818. [Pubmed]

Ramachandra, L., Qu, Y., Wang Y., Lewis, C.J., Cobb, B.A., Takatsu, K., Boom, W.H., Dubyak, G.R., Harding, C.V. (2010) "Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing MHC-II molecules capable of antigen presentation", Infection and Immunity 78(12), pp. 5116-5125. [Pubmed]

Lewis, C.J. and Cobb, B.A. (2010) "Carbohydrate Oxidation Acidifies Endosomes, Regulating Antigen Processing and TLR9 Signaling", Journal of Immunology 184, pp. 3789-3800. [Pubmed]

Brokaw, A., Cobb, B.A. (2009) "A Simple Test Tube-Based ELISA Experiment for the High School Classroom", Biochemistry and Molecular Biology Education 37(4), pp. 243-248. [Pubmed]

Cobb, B.A. (2009) "Immunology and the biomedical student pipeline", European Journal of Immunology 39(5), pp. 1183-1186. [Pubmed]

Velez, C.D., Lewis, C.J., Kasper, D.L., Cobb, B.A. (2008) "Type 1 Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHCII-dependent pathway for antigen presentation", Immunology 127(1), pp. 73-82. [Pubmed]

Clark, N.M., Marinis, J.M., Cobb, B.A., Abbott, D.W. (2008) "MEKK4 sequesters RIP2 to dictate NOD2 signal specificity", Current Biology 18(18), pp. 1402-1408. [Pubmed]

Cobb, B.A., Kasper, D.L. (2008) "Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR", Glycobiology 18(9), pp. 707-718. [Pubmed]

Kreisman, L.S.C., Friedman, J.H., Neaga, A., Cobb, B.A. (2007) “Structure-Function Relationships with a T cell Activating Polysaccharide Antigen using Circular Dichroism”, Glycobiology 17(1), pp. 46-55. [Pubmed]

Wang, Q., McLoughlin, R.M., Cobb, B.A., Charrel-Dennis, M., Zaleski, K.J., Golenbock, D., Tzianabos, A.O., Kasper, D.L. (2006) "A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2", Journal of Experimental Medicine 203(13), pp. 2853-2863. [Pubmed]

Cobb, B.A., Kasper, D.L. (2005) "Zwitterionic Capsular Polysaccharides: The New MHCII-Dependent Antigens", Cellular Microbiology 7(10), pp. 1398-1403. [Pubmed]

Cobb, B.A., Kasper, D.L. (2005) "Coming of Age: Carbohydrates and Immunity", European Journal of Immunology 35(2), pp. 352-356.  [Pubmed]

Cobb, B.A., Wang, Q., Tzianabos, A.O., Kasper, D.L. (2004) "Polysaccharide Processing and Presentation by the MHCII Pathway", Cell 117(5), pp. 677-87.  [Pubmed]

Cobb, B.A., Petrash, J.M. (2002) "Factors Influencing alpha-Crystallin Association with  Phospholipid Vesicles", Molecular Vision 8, pp. 85-93.  [Pubmed]

Cobb, B.A., Petrash, J.M. (2001) "Alpha-Crystallin Chaperone-Like Activity and Membrane Binding in Age-Related Cataracts", Biochemistry 41, pp. 483-90.  [Pubmed]

Cobb, B.A., Petrash, J.M. (2000) "Structural and Functional Changes in the alphaA-crystallin R116C Mutant in Hereditary Cataracts", Biochemistry 39, pp. 15791-8.  [Pubmed]

Cobb, B.A., Petrash, J.M. (2000) "Characterization of alpha-Crystallin-Plasma Membrane Binding", Journal of Biological Chemistry 275(9), pp. 6664-72.  [Pubmed]

Stock, M.F., Guerrero, J., Cobb, B., Eggers, C.T., Huang, T-G, Li, X., Hackney, D.D. (1999) "Formation of the Compact Confomer of Kinesin Requires a COOH-terminal Heavy Chain Domain and Inhibits Microtubule-Stimulated ATPase Activity", Journal of Biological Chemistry 274(21), pp. 14617-23.  [Pubmed]

Third-Party News and Views

(2011) "The curious case of nitric oxide and CGD", In this issue. European Journal of Immunology 41(9), pp. 2465-2466. [Link]

Watts, C. (2004) "Class II MHC: Sweetening the Peptide-Only Diet?", Cell 117(5), pp. 558-9.  [Pubmed]

Honey, K. (2004) "Presenting a Newly Charged Antigen", Nature Reviews Immunology 4, pg. 489.

Hurtley, S.M. (2004) "Immunology: Sweet Presentation", Science 304, pg. 1719.

Dempsey, L.A. (2004) "Processed Sugar", Nature Immunology 5(7), pg. 693.