Editing of the CFTR locus: the impact on chromatin architecture
and gene expression
Department of Genetics and Genome Sciences
Case Western Reserve University
Cleveland, Ohio. USA
The goals of this collaborative research program are to repair mutations in the cystic
fibrosis transmembrane conductance regulator (CFTR) gene, by gene editing.
Errors in CFTR are associated with the common inherited disorder cystic fibrosis. CFTR
has a complex pattern of tissue specific and temporal regulation. The project will involve
1) Definition of CFTR regulatory mechanisms in orphan tissues.
2) CRISPR/Cas9 protocols to manipulate CFTR gene expression.
3) Analysis of the impact of therapeutic gene editing on CFTR locus architecture
and gene expression.
Successful applicants for this CFF funded program will have a strong record of
accomplishment as shown by publications as a graduate student and/or postdoc, be
highly motivated and have a passion for functional genomics research.
Expertise in molecular biology protocols is essential. Familiarity with general techniques
of functional genomics and mammalian cell biology is preferred. We are part of a vibrant
and interactive research community at Case Western Reserve University and occupy
excellent, modern laboratory space.
Please send an electronic letter of application, quoting the reference CWRU/AH1/2024,
Curriculum Vitae and contact information of 3 referees to: firstname.lastname@example.org. Hiring is
contingent upon eligibility to work in the United States.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.