Title: Postdoctoral fellow – Acute Myeloid Leukemia
Department: Pathology
Supervisor Name and Title: Dr. Parameswaran Ramakrishnan, M.S., Ph.D.
I. STATEMENT OF RESEARCH AND SCIENTIFIC RESPONSIBILITIES
This is a key position within the lab and will be responsible for planning and execution of
experiments in close collaboration with the Principal Investigator. The lab is working
closely together with other PI's in Pathology and school of medicine including
collaborations with a multidisciplinary team of biologists, chemists, physicists and
clinicians. The qualified candidate will prepare manuscripts and contribute preliminary
data, background and significance and experimental design for grant proposals.
The focus of the current position is acute myeloid leukemia. Goal is to discover novel
molecular mechanisms that could be targeted to develop new therapeutic approaches.
Regulation of cellular signaling by hexosamine biosynthetic pathway, O-GlcNAcylation
and NF-kB transcription pathways are key areas of attention. The work will involve
experimental techniques ranging from basic cell and molecular biology, immunology,
biochemistry to cell culture, animal studies and patient samples. Experience with mouse
models and flow cytometry is required. The candidate will work independently and should
be competent to read the literature, assist with designing and planning of projects and
carry out research on the assigned project. Expected to apply/secure training fellowships.
II. TECHNICAL SKILLS
1. Design, plan and carry out experiments in collaboration with PI. Provide assistance
and work closely with staff, post-doctoral scholars and graduate students ensuring
projects are being completed according to the research plan. Advise/Assist in
developing improved techniques, project methods, or procedures.
2. Oversee general lab operations including inventory, lab organization and maintain
certain equipment/facilities. Must demonstrate compliance with policies, procedures
and regulations of the Animal Resource Center, IACUC, Animal Welfare Act, Public
Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines
for which essential training will be provided.
3. Analyze and record results. Assist in manuscript preparation.
4. Perform/supervise rodent husbandry including breeding, genotyping and maintain
an accurate animal database.
5. Present results in laboratory meetings and other scientific meetings.
6. Perform other duties as assigned.
III. SUPERVISORY RESPONSIBILIES
Train and oversee rotation students and other research staff
IV. EDUCATION REQUIREMENTS
Ph.D in biological sciences with hands-on experience in Immunology, Biochemistry,
Cell Biology and mouse work.
V. YEARS OF RELEVANT EXPERIENCE REQUIRED
Ph.D with 0-2 years of postdoctoral experience and demonstrated research ability in
the form of lead author publications.
Higher experience will be considered for Research Associate position.
VI. PROPOSED SALARY RANGE – As per NIH scale
DESIRABLE SKILLS
1. Ability to work well with others and to work independently strictly following
directions and protocols.
2. Ability to collect and analyze data with attention to detail and do multiple tasks
simultaneously.
3. Effective oral and written communication skills. Must be able to effectively
communicate with the PI/supervisor as well as other lab members.
4. Good interpersonal skills; ability to work and communicate with various individuals
within and external to the University.
5. Good organization skills; ability to multi-task, prioritize and meet deadlines. Must
demonstrate attention to detail and accuracy and follow-through on assigned tasks.
6. Ability to work effectively independently and collaboratively within a team.
7. Ability to work with sensitive information and maintain confidentiality.
8. Good problem-solving skills; must demonstrate good analytical skills, sound
judgment and good decision-making.
9. Ability to rely on and follow instructions and pre-established guidelines to perform
the functions of the job.
10. Ability to operate laboratory equipment and learn to operate new instruments
11. Familiarity with policies and procedures of lab and chemical safety
12. Knowledge in Microsoft Office, database applications, and with internet
navigation.
13. Willingness to learn new techniques, procedures, processes, and software
programs as needed.
14. Ability to organize, maintain and prepare accurate records
15. Must be willing to adjust working hours according to the nature of ongoing
experiments and many times work extended hours to finish the experiments. Working
on weekends and holidays maybe required depending on the ongoing experiments
and need to accelerate data generation and manuscript and grant preparations.
16. Must demonstrate flexibility and ability to work under pressure; must be able and
willing to conform to shifting priorities, demands and timeline.
17. Self driven effort in terms of thinking, planning, and working is expected.
Application Instructions
HOW TO APPLY
Applicants may send inquiries containing a Curriculum Vitae (CV) with a list of
publications and contact information with references to the Principal Investigator,
Parameswaran Ramakrishnan at pxr150@case.edu.