Title: Postdoctoral fellow
Department: Medicine, Division of Infectious Diseases and HIV Medicine
School: Case Western Reserve University School of Medicine
Location: Biomedical Research Building, 10th Floor
Supervisor: Stephen Carpenter, MD, PhD; Assistant Professor of Medicine
I. STATEMENT OF RESEARCH AND SCIENTIFIC RESPONSIBILITIES
The qualified candidate is responsible for performing and supervising research projects in the field of immunity to Mycobacterium tuberculosis. Research will focus on studying the function of human T cell responses to tuberculosis using primary human cells from blood and bronchoalveolar lavage (BAL) samples of healthy individuals previously infected with Mycobacterium tuberculosis and HIV. Work includes performing experiments, data analysis, oral and written presentation of results, writing manuscripts for publication and grant proposals for funding from the main funding entities (NIH, NIAID). Candidates should be highly experienced in standard immunology research techniques and data analysis. Strongest consideration will be give to candidates with experience in bioinformatics anlysis of next-generation sequencing data (RNA / DNA sequencing and single-cell RNAseq).
The position provides an opportunity to make exciting discoveries and impact the fields of infectious disease and immunology, which includes performing experiments in a biosafety level 3 (BSL-3) lab, working with human cells, and sequencing data analysis.
II. TECHNICAL SKILLS
- A high level of experience with standard immunology techniques is essential. Required techniques include: immunomagnetic cell isolation, flow cytometry, ELISA/ELISPOT, fluorescent microscopy, PCR and qPCR. Experience with cell sorting is preferred.
- Experience working with with human or murine immune cell samples is required.
- Experience with data analysis systems such as: Prism, Flowjo, microsoft excel is required.
- Experience with R and required packages (e.g. Seurat) is preferred.
- Experience independently writing manuscripts for submission to peer-reviewed journals is required.
- Experience with analysis of next-generation sequencing data (DNA/RNAseq, single-cell RNA sequencing, TCR sequencing) is preferred.
III. SUPERVISORY RESPONSIBILITIES
- Supervise laboratory technicians/assistants and student trainees in experimental design and data analysis of a variety of projects.
IV. EDUCATION REQUIREMENTS
- Minimum qualifications include a Ph.D. in immunology, microbiology or equivilent.
- Experience with in vitro human or murine live T cell assays, flow cytometry, and in vivo assays in mouse or non-human primate models is essential.
- The successful candidate must have strong analytical, oral and written communication skills.
- Experience managing graduate students and/or research technicians is preferred
Send inquiries containing a cover letter, CV with list of publications and contact information for three references to: stephen.carpenter@case.edu