Postdoctoral Scholar
Kim Laboratory
Department of Biochemistry, School of Medicine –
Postdoctoral Scholar position in NMR Spectroscopy & Cryo-EM
JOB SUMMARY
We have an exciting postdoctoral position available at Case Western Reserve University to
delve into the structure and dynamics of nucleosomes and chromatin. Our mission? We aim to
decipher the detailed mechanisms by which transcription factors, DNA damage response
proteins, and epigenetic modifications alter chromatin's structure and interaction dynamics at a
molecular level. By gathering atomic resolution information, we seek to make notable
contributions to the understanding of chromatin's role in cellular mechanisms. As a
postdoctoral scholar, you will pioneer projects designed to elucidate how transcription factors,
DNA damage response proteins, and epigenetic modifications induce changes in chromatin's
structure, dynamics, and interactions at a molecular scale. To achieve our objectives, we use a
multidisciplinary methodology, utilizing biophysical tools such as NMR and cryo-EM, alongside
molecular biology, protein chemistry, and fluorescence microscopy. You can learn more about
our work by visiting our relevant publications here:
https://scholar.google.ca/citations?user=SspbtpEAAAAJ&hl=en OR
https://www.thkimlab.com/
The Department of Biochemistry has a highly interactive environment with state-of-the-art core
facilities (mass spectrometry, cytometry, microscopy, biophysics and structural biology). The
NMR facility at Case Western Reserve University houses excellent solution NMR spectrometers
(Bruker 600, 700, 800 and 900 MHz) with the 600 and 700 MHz spectrometers upgraded with
new consoles. Also, the cryo-EM facility houses state-of-the-art electron microscopes in a newly
renovated space including FEI Titan Krios G3i 300 kV, FEI Tecnai TF20 (200kV, FEG), and a brand
new Glacios Cryo-TEM (200kV). Competitive stipends and benefits packages are available.
QUALIFICATIONS
Experience: 0-3 years of postdoctoral experience in the Biochemistry/Structural Biology. PhD
students and postdoctoral scholars in other fields such as Biology, Chemistry, Physics or
Genetics are also encouraged to apply.
Education/Licensing: Ph.D. or M.D./Ph.D. in Chemistry, Physics, Biochemistry, or Biology.
DESIRED SKILLS
Experience with structural biology (NMR, cryo-EM, and x-ray crystallography)
and biophysical techniques (ITC, DSC, MST, and DLS)
Experience with expression (E. coli, yeast, and mammalian cells) and purification of proteins or
nucleic acids
Experience with mammalian cell culture and imaging
Competent in molecular biology (cloning, and site-directed mutagenesis)
Basic/advanced computer programming (Python, MATLAB, or R)
Proficient in scientific writing
APPLICANT INSTRUCTIONS
Interested candidates should send a cover/motivation letter and a CV with the names and
contact information of 2-3 references to Tae Hun Kim (txk560@case.edu).
Case Western Reserve University is committed to Equal Opportunity and Diversity. Women,
veterans, members of underrepresented minority groups, and individuals with disabilities are
highly encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with
disabilities. Applicants requiring a reasonable accommodation for any part of the application
and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at
216-368-8877 to request a reasonable accommodation. Determinations as to granting
reasonable accommodations for any applicant will be made on a case-by-case basis.