Postdoctoral Scholar, Case Western Reserve University School of Medicine, Division of Cancer Biology, MetroHealth Medical Center, Cleveland, OH, United States
A Postdoctoral position in Cancer translational research and metastasis is available in Dr. Sossey-Alaoui’s laboratory at the Division of Cancer Biology, MetroHealth Medical Center, and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Our research focuses on the basic molecular mechanisms underlying cancer invasion and metastasis as well as interactions within the tumor microenvironment in major solid tumor cancers, with a focus on breast, prostate and brain cancers. Highly motivated cancer biologists with Ph.D., M.D., or both degrees, and proven record of research creativity and productivity are welcome to apply. Working experience using transgenic/knockout and xenograft mouse models, Cell Signaling and basic molecular biology techniques is valuable; familiarity with CRSPR/Cas9, cancer stem cells, bioinformatics, or Drug Discovery is a plus. Competitive salary and generous benefit package will be provided for qualified candidates. Case Western Reserve University is an equal opportunity employer.
The Postdoctoral position is available immediately. Interested candidates should send their CV, and contact information for three references to Dr. Sossey-Alaoui at kxs586@case.edu.
Please refer to the most recent publications for details:
Yousafzai N, El Khalki L, Wang W, Szpendyk J, Sossey-Alaoui K. Kindlin-2 Regulates the Oncogenic Activities of Integrins and TGF-β In Triple Negative Breast Cancer Progression and Metastasis. Oncogene. 2024 Nov;43(45):3291-3305. PMID: 39300257.
Verrillo CE, Quaglia F, Shields CD, Lin S, Kossenkov AV, Tang HY, Speicher D, Naranjo NM, Testa A, Kelly WK, Liu Q, Leiby B, Musante L, Sossey-Alaoui K, Dogra N, Chen TY, Altieri DC, Languino LR. Expression of NgR2, downstream effector of the αVβ3 integrin, in small extracellular vesicles increases prostate cancer growth in vivo. J Extracellular Vesicles. 2024 Aug 13(8):e12482. PMID: 39105261.
Time-resolved live-cell spectroscopy reveals EphA2 multimeric assembly. Shi X, Lingerak R, Herting CJ, Ge Y, Kim S, Toth P, Wang W, Brown BP, Meiler J, Sossey-Alaoui K, Buck M, Himanen J, Hambardzumyan D, Nikolov DB, Smith AW, Wang B. Science. 2023 Dec;382(6674):1042-1050. PMID: 37972196.
Rana PS, Wang W, Alkrekshi A, Markovic V, Khiyami A, Chan R, Perzynski A, Joseph N, Sossey-Alaoui K. YB1 Is a Major Contributor to Health Disparities in Triple Negative Breast Cancer. Cancers. 2021 Dec 14;13(24):6262. PMID: 34944882
Kansakar U, Wang W, Markovic V, Sossey-Alaoui K. Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer. Sci Rep. 2021 Feb 16;11(1):3868.
Sossey-Alaoui K, Pluskota E, Bialkowska K, Szpak D, Parker Y, Morrison C, Lindner DJ, Schiemann WP, Plow EF. Kindlin-2 regulates the growth of breast cancer tumors by activating CSF-1-mediated macrophage infiltration. Cancer Res. 2017 Sep 15;77(18):5129-5141.
MetroHealth Center for Cancer Research Website:
https://www.metrohealth.org/center-for-cancer-research/researchers/khalid-sossey-alaoui List of Publications:
https://pubmed.ncbi.nlm.nih.gov/?term=%28sossey
alaoui%29+NOT+%28Geffard%29&sort=pubdate