CWRU Cardiovascular Research Institute

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Recent Publications

KLF2 and KLF4 control endothelial identity and vascular integrity. Sangwung P, Zhou G, Nayak L, Chan ER, Kumar S, Kang DW, Zhang R, Liao X, Lu Y, Sugi K, Fujioka H, Shi H, Lapping SD, Ghosh CC, Higgins SJ, Parikh SM, Jo H, Jain MK., 2017 Feb 23

BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.Willis MS, Holley DW, Wang Z, Chen X, Quintana M, Jensen BC, Tannu M, Parker J, Jeyaraj D, Jain MK, Wolfram JA, Lee HG, Bultman SJ. J Mol Cell Cardiol. 2017 Feb 20.

miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet AH, Shimizu C, Jain MK, Burns JC, Shyy JY.Circ Res. 2017 Jan 20;120(2):354-365.

Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention. Chowdhury SK, Liu W, Zi M, Li Y, Wang S, Tsui H, Prehar S, Castro S, Zhang H, Ji Y, Zhang X, Xiao R, Zhang R, Lei M, Cyganek L, Guan K, Millar CB, Liao X, Jain MK, Boyett MR, Cartwright EJ, Shiels HA, Wang X.Circulation. 2017 Feb 14; 135(7):683-699.

Experimental Lung Injury Reduces KLF2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling. Huang RT, Wu D, Meliton A, Oh MJ, Krause M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, Kress JP, Birukov KG, Mutlu GM, Fang Y. Am J Respir Crit Care Med. 2016 Nov 17. [Epub ahead of print]

Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6Clow Monocytes while Preserving Macrophage Gene Function. Thomas GD, Hanna RN, Vasudevan NT, Hamers AA, Romanoski CE, McArdle S, Ross KD, Blatchley A, Yoakum D, Hamilton BA, Mikulski Z, Jain MK, Glass CK, Hedrick CC.Immunity. 2016 Nov 15;45(5):975-987. doi: 10.1016/j.immuni.2016.10.011.

Genome-wide analysis of long intergenic non-coding RNAs in chickpea and their potential role in flower development. Khemka N, Singh VK, Garg R, Jain M. Sci Rep. 2016 Sep 15;6:33297. doi: 10.1038/srep33297.

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting. Takeuchi Y, Yahagi N, Aita Y, Murayama Y, Sawada Y, Piao X, Toya N, Oya Y, Shikama A, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Yamamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Urayama O, Kawakami Y, Iizuka Y, Gotoda T, Itaka K, Kataoka K, Nagai R, Kadowaki T, Yamada N, Lu Y, Jain MK, Shimano H Cell Rep. 2016 Aug 30;16(9):2373-86. doi: 10.1016/j.celrep.2016.07.069.

Exercise-induced endobronchial hemorrhage: a rare clinical presentation. Kruavit A, Jain M, Fielding D, Heraganahally S. Respirol Case Rep. 2016 May 5;4(4):e00163. doi: 10.1002/rcr2.163.

Incidentally detected ectopic ampulla of vater in the antrum in a patient of colonic tuberculosis. Jain M, Rai GP, Pokharna RK, Nepalia S, Ashdhir P.Trop Gastroenterol. 2015 Oct-Dec;36(4):283-5. No abstract available.

Reduced Krüppel-Like Factor 2 Aggravates Glomerular Endothelial Cell Injury and Kidney Disease in Mice with Unilateral Nephrectomy. Zhong F, Mallipattu SK, Estrada C, Menon M, Salem F, Jain MK, Chen H, Wang Y, Lee K, He JC.Am J Pathol. 2016 Aug;186(8):2021-31. doi: 10.1016/j.ajpath.2016.03.018.

Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis.Xiong Y, Lingrel JB, Wüthrich M, Klein BS, Vasudevan NT, Jain MK, George M, Deepe GS Jr. MBio. 2016 Jun 14;7(3). pii: e00436-16. doi: 10.1128/mBio.00436-16.

Krüppel-Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers. Mallipattu SK, Guo Y, Revelo MP, Roa-Peña L, Miller T, Ling J, Shankland SJ, Bialkowska AB, Ly V, Estrada C, Jain MK, Lu Y, Ma'ayan A, Mehrotra A, Yacoub R, Nord EP, Woroniecki RP, Yang VW, He JC. J Am Soc Nephrol. 2017 Jan; 28(1):166-184. doi: 10.1681/ASN.2015060672.

Characterization of Rice Homeobox Genes, OsHOX22 and OsHOX24, and Over-expression of OsHOX24 in Transgenic Arabidopsis Suggest Their Role in Abiotic Stress Response. Bhattacharjee A, Khurana JP, Jain M.Front Plant Sci. 2016 May 10; 7:627. doi: 10.3389/fpls.2016.00627.

RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS.Dixit AB, Banerjee J, Srivastava A, Tripathi M, Sarkar C, Kakkar A, Jain M, Chandra PS.Genomics. 2016 May; 107(5):178-88. doi: 10.1016/j.ygeno.2016.04.001.

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y.Circulation. 2016 May 24; 133(21):2038-49. doi: 10.1161/CIRCULATIONAHA.115.020226.

Transcriptome analysis in different rice cultivars provides novel insights into desiccation and salinity stress responses. Shankar R, Bhattacharjee A, Jain M. Sci Rep. 2016 Mar 31; 6:23719. doi: 10.1038/srep23719.

De Novo Transcriptome Analysis of Medicinally Important Plantago ovata Using RNA-Seq. Kotwal S, Kaul S, Sharma P, Gupta M, Shankar R, Jain M, Dhar MK. PLoS One. 2016 Mar 4; 11(3):e0150273. doi: 10.1371/journal.pone.0150273.

De novo transcriptome assembly and comprehensive expression profiling in Crocus sativus to gain insights into apocarotenoid biosynthesis.Jain M, Srivastava PL, Verma M, Ghangal R, Garg R.Sci Rep. 2016 Mar 3; 6:22456. doi: 10.1038/srep22456.

Endoscopic management of pancreatic pseudocysts and walled-off pancreatic necrosis: A two-decade experience.Sharma SS, Singh B, Jain M, Maharshi S, Nijhawan S, Sapra B, Jhajharia A. Indian J Gastroenterol. 2016 Jan; 35(1):40-7. doi: 10.1007/s12664-016-0624-5.

Contact Information

Iris S. and Bert L. Wolstein Research   Building
2103 Cornell Road
Office: WRB 4-522
Lab: WRB 4-503

216-368-2036 (Phone)
216-368-7290 (Fax)
mukesh.jain2@case.edu