Department of Biomedical Engineering
  
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Applied Neural Control: J.T. Mortimer
  
   
Wed. May 01 2024
   
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Block AP - Preliminaries
Unidirectional Propagation
Selective Activation
Electrochemistry
Tissue Response:
Brain |Nerve| Muscle
 
 
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Tissue Response: Muscle : Page 3

Imbalanced Biphasic Pulse.

The results of Mortimer et al. (1980) indicate that imbalanced biphasic stimuli can be tissue safe at higher and can avoid damage to the electrode.

 

Anodic and Cathodic Charge.

Figure plots charge densities in relation to electrode corrosion and tissue damage.
Oblique lines plot the degree of charge imbalance. The left-most one with no imbalance, with progressive increase in cathodic charge, moving to the right. These data indicate that the damaged area was significantly greater than control values.

 

Lipid Peroxidation.

Postulated mechanisms for damage by free radicals are shown in the Figure.

 
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