Zhuliw Wan Ph. D. Instructor, Department of Biochemistry E-mail: wan@biochemistry.cwru.edu Telephone: (216) 368-8682 FAX: (216) 368-4458

I am interested in macromolecular crystallography. I undertake the crystal structure of novel insulin analogs under investigation in diabetes research. My x-ray studies will cohere with complementary ongoing studies of insulin analogs by Dr. Weiss's laboratory using NMR spectroscopy.
An additional focus is study of the crystal structure and function relationship of a DNA-binding motif encoded by the human sex region of Y-chromosome protein. This work has important implications for the molecular basis of human birth defects.

Selected Publications:

Liu Jinyu, Zhang jiping, Wan Zhuli etal.,
Crystallization and preliminary x-ray studies of Allophycocyanin from red alga porphyra yezoensis,
Acta Cryst. D54 (1988), 662-664.
Dao Jiashen, Wan Zhuli etal.,
Structure of monomeric porcine DesB1-2 despentapeptide(B26-30) insulin at 1.65 A.
Acta Cryst. D53(1997), 507-512
Chang Wenrui, Jiang Tao, Wan Zhuli etal,
Crystal structure of R-phycoerythin from Polysiphonia Urceolata at 2.8 resolution.
J.Mol.Biol. 262(1996), 721-731.
Cunhui Zhan, Wan Zhuli, etal.,
Crystallization and preliminary x-ray diffraction studies of recombinant staphylokinase.
Acta Crysta. D52(1996), 564-565.
Liang dongcai, Jiangtao, Zhang Jiping Wan Zhuli etal.,
Li shenggyang, Gui Lulu, Lin Zhihuan, Wan Zhuli etal.,
Purification and crystal growth of A1-ATPase from pig heart mitochondria,
Biochemistry and Molecular Biology International, 40(1996),3:479-486

Academic Experience