Case Western Reserve University

Martin Snider, Ph.D.

Professor

Education

• Ph.D.: Harvard University, 1978
• Postdoc: Massachusetts Institute of Technology

Research Interests

My work is a collaboration with Dr. Maria Hatzoglou in the Nutrition Department. We are interested in the cellular responses to stresses, including nutrient starvation, viral infection and the accumulation of unfolded proteins. The responses to mild stress lead to the expression of proteins that promote survival, whereas severe stress induces cell death (apoptosis). Our studies focus on the regulatory mechanisms that control both transcription and translation; working together, these mechanisms control the balance between expression of proteins that promote survival or apoptosis.

Selected References

• Majumder, M., Yaman, I., Gaccioli, F., Zeenko, V. V., Wang, C., Caprara, M. G., Venema, R. C., Komar, A. A., Snider, M. D., Hatzoglou, M.
  “The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation.”
  Mol Cell Biol 29, 2899-2912 (2009)
• Zeenko, V. V., Wang, C., Majumder, M., Komar, A. A., Snider, M. D., Merrick, W. C., Kaufman, R. J., Hatzoglou, M.
  “An efficient in vitro translation system from mammalian cells lacking the translational inhibition caused by eIF2 phosphorylation.”
  RNA 14, 593-602 (2008)
• Li, Y., Bevilacqua, E., Chiribau, C. B., Majumder, M., Wang, C., Croniger, C. M., Snider, M. D., Johnson, P. F., Hatzoglou, M.
  “Differential control of the CCAAT/enhancer-binding protein beta (C/EBPbeta) products liver-enriched transcriptional activating protein (LAP) and liver-enriched transcriptional inhibitory protein (LIP) and the regulation of gene expression during the response to endoplasmic reticulum stress.”
  J Biol Chem 283, 22443-22456 (2008)
• Fernandez, J., Yaman, I., Huang, C., Liu, H., Lopez, A. B., Komar, A. A., Caprara, M. G., Merrick, W. C., Snider, M. D., Kaufman, R. J., Lamers, W. H., Hatzoglou, M.
  “Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation.”
  Mol Cell 17, 405-416 (2005)
• Yaman, I., Fernandez, J., Liu, H., Caprara, M., Komar, A. A., Koromilas, A. E., Zhou, L., Snider, M. D., Scheuner, D., Kaufman, R. J., Hatzoglou, M.
  “The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader.”
  Cell 113, 519-531 (2003)