2018 Wharton Summer Student Research Fellows
Congratulations to the following 2018 Wharton Summer Research Fellows:
Causes of the side-effects of β-alanine after it is ingested by athletes with the intent to boost muscular performance
Henri Brunengraber, PhD, MD
Impact of education and training in research during a master's degree program on research participation among RDN alumni: the CWRU combined dietetic internship/master's degree program experience
Rosa K. Hand, MS, RDN, LD, FAND
Stephanie Harris, PhD, RDN, LD
Vitamin E: nutrient-gene interactions
No video available. Contact Dr. Manor directly for all questions related to this study.
Alpha-tocopherol (vitamin E) is a plant-derived dietary lipid that is essential for human health. The vitamin is known to function as a lipid anti-oxidant that prevents and ameliorates oxidative stress in the nervous and reproductive systems. Despite its established importance for human health, intake of vitamin E in the US population is far below recommended levels. Moreover, the exact molecular mechanisms by which tocopherol offers protection from disease are poorly understood.
We recently found that in addition to its established function in combating oxidative stress, vitamin E has novel, antioxidant-independent functions. Specifically, it directly regulates the expression of a vitamin E transporter in neurons and in liver cells. These novel findings indicate that the levels and distribution of vitamin E in the body are homeostatically-controlled and regulated.
The project is aimed to elucidate how vitamin E regulates gene expression. Student will gain a deep understanding of the literature on nutrient-gene-gene interactions (through guided readings and discussions), and learn basic concepts and techniques required for studying gene expression in cultured cells. Major experimental approaches include mammalian cell culture, analyses of mRNA expression, optical and fluorescence microscopy, and relevant biochemical assays. Student will write a short summary paper upon conclusion of the project.
NOTE: Requirements: coursework in Biochemistry and Physiology. One-day formal training in laboratory safety will be carried out prior to project onset.
• Understand how nutrients affect cell physiology by altering gene expression.
• Gain proficiency in experiment design, execution, and data analysis.
Danny Manor, PhD
Retail Food Environments
Assessing and validating the retail food environment surrounding schools in low-income neighborhoods
Catherine Rogers, PhD, MS, RDN
Immunohistologic Analyses of Excess Dietary Iron and Intestinal Tumorigenesis
James Swain, PhD, RD, LD, FAND
Exomes as Biomarkers
Purifying exomes for use as biomarkers
Tilton Summer Research for full project description (PDF).
John Tilton, MD
Exploring the association among estrogen receptors, gut hormones, and disordered eating behaviors in female athletes
Lynn Cialdella Kam, PhD, MBA, RDN, LD
Sichun Yang, PhD
Exploring pediatric obesity treatment in a pediatric primary care setting
Rosana Watowicz, PhD, RD, LD
Catherine Rogers. PhD, MS, RD
The role of macrophage polarization in the development of sepsis
Colleen Croniger, PhD