Andrew E. Sloan, MD

Professor and Vice Chair of Research
Department of Neurological Surgery
School of Medicine
Professor
Department of Pathology
School of Medicine
Member
Developmental Therapeutics Program
Cancer Imaging Program
Case Comprehensive Cancer Center

Research Information

Research Interests

  • Brain tumors
  • Convection Enhanced Delivery (CED)
  • Gamma Knife and Cyberknife Stereotactic Radiosurgery
  • Image Guided Neurosurgery
  • Neurosurgery
  • Skull Base Surgery
  • Stereotactic Surgery
  • Tumor Vaccines (Immunotherapy)

External Appointments

Director, Brain Tumor and Neuro-Oncology Center
University Hospitals Cleveland Medical Center
Vice Chairman, Department of Neurological Surgery
University Hospitals Cleveland Medical Center
Medical Director, Neuro-Oncology
University Hospitals Cleveland Medical Center

Publications

View All Publications

Cheng L, Huang Z, Zhou W, Wu Q, Donnola S, Liu JK, Fang X, Sloan AE, Mao Y, Lathia JD, Min W, McLendon RE, Rich JN, Bao S. Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell. 2013 Mar 28;153(1):139-52. doi: 10.1016/j.cell.2013.02.021. PubMed Central PMCID: PMC3638263.

Sloan AE, Ahluwalia MS, Valerio-Pascua J, Manjila S, Torchia MG, Jones SE, Sunshine JL, Phillips M, Griswold MA, Clampitt M, Brewer C, Jochum J, McGraw MV, Diorio D, Ditz G, Barnett GH. Results of the NeuroBlate System first-in-humans Phase I clinical trial for recurrent glioblastoma: clinical article. Journal of Neurosurgery. 2013 Jun;118(6):1202-19. doi: 10.3171/2013.1.JNS1291. Epub 2013 Apr 5.

Vengoechea J, Sloan AE, Chen Y, Guan X, Ostrom QT, Kerstetter A, Capella D, Cohen ML, Wolinsky Y, Devine K, Selman W, Barnett GH, Warnick RE, McPherson C, Chiocca EA, Elder JB, Barnholtz-Sloan JS. Methylation markers of malignant potential in meningiomas. Journal of Neurosurgery. 2013 Oct;119(4):899-906. doi: 10.3171/2013.7.JNS13311. 

Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O'Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L; TCGA Research Network. The somatic genomic landscape of glioblastoma. Cell. 2013 Oct 10;155(2):462-77. doi: 10.1016/j.cell.2013.09.034.

Block O, Crane C, Fuks Y, Kaur R, Kim J, Aghi M, Berger M, Butowski N, Chang S, Clarke J, McDermott MW, Prados MD, Sloan AE, Bruce J, Parsa AT.   Autologous Heat Shock Protein Peptide Complex-96 (HSPPC-96) Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial. Neuro Oncol. 2014 Jan;16(2):274-9. [Epub ahead of print 12/12/13].  PMID24335700.

Flavahan WA, Wu Q, Hitomi M, Rahim N, Kim Y, Sloan AE, Weil RJ, Nakano I, Sarkaria JN, Stringer BW, Day BW, Li M, Lathia JD, Rich JN, Hjelmeland AB. Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake. Nat Neurosci. 2013 Oct;16(10):1373-82. doi: 10.1038/nn.3510. Epub 2013 Sep 1.

Bambakidis NC, Selman WR, Sloan AE. Surgical rehearsal platform: potential uses in microsurgery. Neurosurgery. 2013 Oct;73 Suppl 1:S122-6. doi: 10.1227/NEU.0000000000000099.

Guan X, Vengoechea J, Zheng S, Sloan AE, Chen Y, Brat DJ, O’Neill BP, de Groot J, Yust-Katz S, Yung WK, Cohen ML, Aldape KD, Rosenfeld S, Verhaak RG, Barnholtz-Sloan JS.  Molecular subtypes of glioblastoma are relevant to lower grade glioma. PloS One.  2014 Mar 10;9(3):e91216. doi:  10.1371/journal.pone.0091216.eCollection 2014.  PMID:  24614622 PubMed PMC 3948818.

Gittleman HR, Ostrom QT, Rouse CD, Dowling JA, de Blank PM, Kruchko CA, Elder JB, Rosenfeld SS, Selman WR, Sloan AE, Barnholtz-Sloan JS. Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010. Cancer. 2014 Aug 25. doi: 10.1002/cncr.29015. [Epub ahead of print] PubMed PMID: 25155924.

Lo SS, Sloan AE, Machtay M. Stereotactic radiosurgery for more than four brain metastases. Lancet Oncol. 2014 Apr;15(4):362-3. doi: 10.1016/S1470-2045(14)70076-2. Epub 2014 Mar 10. PubMed PMID: 24621619.

Sundar SJ, Hseih JK, Manjila S, Lathia J, Sloan AE:  The role of Cancer Stem Cells in Glioblastoma.  Neurosurgery Focus, 2014 Dec;37(6):E6. doi: 10.3171/2014.9.FOCUS14494. PubMed PMID: 25434391.

Schuster J, Lai RK, Recht LD, Reardon DA, Paleologos NA, Groves MD, Mrugala MM, Jensen R, Baehring JM, Sloan A, Archer GE, Bigner DD, Cruickshank S, Green JA, Keler T, Davis TA, Heimberger AB, Sampson JH. A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study. Neuro Oncol. 2015 Jan 13. pii: nou348. [Epub ahead of print] PubMed PMID: 25586468.

Cancer Genome Atlas Research Network,  Brat DJ et al, (including Sloan AE and >100 others) Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med. 2015 Jun 25;372(26):2481-98. doi: 10.1056/NEJMoa1402121. Epub 2015 Jun 10. PubMed PMID: 26061751.

Education

Doctor of Medicine
Harvard Medical School
1990

Residency

Fellow, Neurosurgical Oncology
MD Anderson Cancer Center
Resident, Neurological Surgery
UCLA School of Medicine
Intern, General Surgery
UCLA School of Medicine