Fifteen Case Western Reserve University alumni and former faculty members have earned the illustrious Nobel Prize over the years.
- Albert Michelson (1907)
- John J.R. Macleod (1923)
- Frederick C. Robbins (1954)
- Polycarp Kusch (1955)
- Donald A. Glaser (1960)
- Earl W. Sutherland Jr. (1971)
- Paul Berg (1980)
- George H. Hitchings (1988)
- Alfred G. Gilman (1994)
- George A. Olah (1994)
- Frederick Reines (1995)
- Ferid Murad (1998)
- Peter Agre (2003)
- Paul C. Lauterbur (2003)
- Edward C. Prescott (2004)