Interests: Biotransport applications to Cell and Tissue Engineering, Microvascular tissue engineering
Microvascular Tissue Engineering: Tissue engineering has the potential to revolutionize healthcare. A significant challenge in tissue engineering is to overcome substrate mass transfer limitations, which if ignored can result in a product that will not function adequately. The main goal of this research is to design and build microvascular flow analogs that can be used to overcome nutrient limitations in tissue-engineered products. Cell Transport: Cell transport is important in several physiological and pathological processes such as inflammation, embryogenesis, cancer metastasis and wound healing. Several mechanisms of cell transport have been identified: passive transport through random diffusion and active transport via convection and mechanisms such as chemotaxis, chemokinesis, and haptotaxis. The main goal of this research is to understand various mechanisms of cell transport and to modulate the growth of cell monolayers.
Fattahi, P.; Rahimian, A.; Kihak, G.; Gonzalez-Suarez, A.; Slama, M.; Wolf, J.; Baskaran, H.; Stybayeva, Peterson, Q.; Duffy, C.; and Revzin, A.: Encapsulation and differentiation of human pluripotent stem cells in core-shell hydrogel microcapsules. Scientific Reports, 2021, (Accepted)
Gong, X.; Yang, P.; Rohm, K.; Zhong, Y.; Zhao, B.; Manas-Zloczower, I.; Baskaran, H.; and Feke. D.L.: Porous hollow fibers with controllable structures templated from high internal phase emulsions. Journal of Applied Polymer Science, 2021, (Accepted)
Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 Jan 26. doi: 10.1089/ten.TEA.2020.0144. Online ahead of print. PMID: 33499734
Chariou, P.L.; Dogan, A.B.; Welsh, A.G.; Saidel, G.M.; Baskaran, H.; and Steinmetz, N.F.: Soil mobility of synthetic and virus-based model nanopesticides. Nat Nanotechnol. 2019 14(7):712-718. doi: 10.1038/s41565-019-0453-7. PMID: 31110265, PMCID: PMC6988359
Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 46(11):1896-1910, 2018, PMID: 29948374, PMCID: PMC6204100
Wang, K-C.; Egelhoff, T.T.; Caplan, A.I.; Welter, J.F.; Baskaran, H.: ROCK Inhibition promotes development of chondrogenic tissue by improved mass transport, Tissue Engineering Part A, 2018, PMID: 29397789, PMCID: PMC6080111
Chou, C.L.; Rivera, A.L.; Williams, V.; Welter, J.F.; Mansour, J.M.; Drazba, J.A.; Sakai, T.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. Acta Biomater. 2017 15(60):210-219 PMID: 28709984 PMCID: PMC5581212
Chung, C.Y.; Heebner, J.; Baskaran, H.; Welter, J.F.; and Mansour, J.M.: Ultrasound elastography for estimation of regional strain of multilayered hydrogels and tissue-engineered cartilage. Ann Biomed Eng. 2015 43(12):2991-3003.
Thomas, D.G.; Yenepalli, A.; Denais, C.M.; Rape, A.; Beach, J.R.; Wang, Y.L.; Schiemann, W.P.; Baskaran, H.; Lammerding, J.; and Egelhoff, T.T.: Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion. Journal of Cell Biology. 2015, 210(4):583-594. doi: 10.1083/jcb.201502039.
Rivera, A.L. and Baskaran, H.: The effect of biomolecular gradients on mesenchymal stem cell chondrogenesis under shear stress. Micromachines 2015, 6(3):330-346. doi:10.3390/mi6030330.
Prologo, J.D.; Duesler, L.; Berilla,J.A.; Baskaran, H.; Schluchter, M.D.; and Welter, J.F.: Impact of concurrent pressure and shear on MSC viability and differentiation during simulated intervertebral disk needle injection. Journal of Vascular and Interventional Radiology 2014 (Submitted)