Recent Publications | Center for Modular Manufacturing of Structural Tissues

Review recent publications by members of the Center for Modular Manufacturing of Structural Tissues.

Gwon, K.; Hong, H.J.; Gonzalez-Suarez, A.M.; Slama, M.Q.; Choi, D.; Hong, J.; Baskaran, H.; Stybayeva, G.; Peterson, Q.P.; and Revzin, A.: Bioactive hydrogel microcapsules for guiding stem cell fate decisions by release and reloading of growth factors Bioactive Materials, 2022. PMID: 35386345, PMCID: PMC8941170, doi: 10.1016/j.bioactmat.2021.12.008

Fattahi, P.; Rahimian, A.; Kihak, G.; Gonzalez-Suarez, A.; Slama, M.; Wolf, J.; Baskaran, H.; Stybayeva, Peterson, Q.; Duffy, C.; and Revzin, A.: Core-shell hydrogel microcapsules enable formation of human pluripotent stem cell spheroids and their cultivation in a stirred bioreactor Scientific Reports, 2021, 11(1):7177 PMID:33785778, PMCID: PMC8010084, DOI:10.1038/s41598-021-85786-2

Gong, X.; Yang, P.; Rohm, K.; Zhong, Y.; Zhao, B.; Manas-Zloczower, I.; Baskaran, H.; and Feke. D.L.: Porous hollow fibers with controllable structures templated from high internal phase emulsions. Journal of Applied Polymer Science, 2021, doi: https://doi.org/10.1002/app.50739

Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 27(19-20):1321-1332 doi: 10.1089/ten.TEA.2020.0144. Online ahead of print. PMID: 33499734

Chariou, P.L.; Dogan, A.B.; Welsh, A.G.; Saidel, G.M.; Baskaran, H.; and Steinmetz, N.F.: Soil mobility of synthetic and virus-based model nanopesticides. Nat Nanotechnol. 2019 14(7):712-718. doi: 10.1038/s41565-019-0453-7. PMID: 31110265, PMCID: PMC6988359

Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 46(11):1896-1910, 2018, PMID: 29948374, PMCID: PMC6204100

Chou, C.L.; Rivera, A.L.; Williams, V.; Welter, J.F.; Mansour, J.M.; Drazba, J.A.; Sakai, T.; and Baskaran, H.: Micrometer scale guidance of mesenchymal stem cells to form structurally oriented large-scale tissue engineered cartilage. Acta Biomater. 2017 15(60):210-219 PMID: 28709984 PMCID: PMC5581212

Chung, C.Y.; Heebner, J.; Baskaran, H.; Welter, J.F.; and Mansour, J.M.: Ultrasound elastography for estimation of regional strain of multilayered hydrogels and tissue-engineered cartilage. Ann Biomed Eng. 2015 43(12):2991-3003.

Thomas, D.G.; Yenepalli, A.; Denais, C.M.; Rape, A.; Beach, J.R.; Wang, Y.L.; Schiemann, W.P.; Baskaran, H.; Lammerding, J.; and Egelhoff, T.T.: Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion. Journal of Cell Biology. 2015, 210(4):583-594. doi: 10.1083/jcb.201502039.

Rivera, A.L. and Baskaran, H.: The effect of biomolecular gradients on mesenchymal stem cell chondrogenesis under shear stress. Micromachines 2015, 6(3):330-346. doi:10.3390/mi6030330.

Prologo, J.D.; Duesler, L.; Berilla,J.A.; Baskaran, H.; Schluchter, M.D.; and Welter, J.F.: Impact of concurrent pressure and shear on MSC viability and differentiation during simulated intervertebral disk needle injection. Journal of Vascular and Interventional Radiology 2014 (Submitted)

Thomas J. Bollenbach

Climov, M.; Matar, A.J.; Farkash, E.A.; Medeiros, E.; Qiao, J.; Harrington, E.; Gusha, A.; Al-Musa, A.; Sachs, D.H.; Randolph, M.; Bollenbach, T.J.; and Huang, C.A.: Survival of allogeneic self-assembled cultured skin. Transplantation, 2016, 100(10):2071-2078. PMCID: PMC5030145; PMID: 27479166

Climov, M.; Medeiros, E.; Farkash, E.A.; Qiao, J.; Rousseau, C.F.; Dong, S.; Zawadzka, A.; Racki, W.J.; Al-Musa, A.; Sachs, D.H.; Randolph, M.A.; Huang, C.A.; and Bollenbach, T.J.: Bioengineered self-assembled skin as an alternative to skin grafts. Plast Reconstr Surg Glob Open, 2016, 4(6):e731. PMCID: PMC4956843, PMID: 27482479

Arnold I. Caplan

Breitman M, Bonfield TL, Caplan AI, Lazarus HM, Haghiac M, LaSalvia S, Reese-Koc J, Singer NG.: Optimization of Human Mesenchymal Stem Cells for Rheumatoid Arthritis: Implications for Improved Therapeutic Outcomes. ACR Open Rheumatol. 2022 4(2):152-160. doi: 10.1002/acr2.11356.PMID: 34792869

Sorrel, J.M.; Somoza, R.A.; Baber, M.A.; Kenyon. J.; and Caplan. A.I.: Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells During Wound Healing. Cells. (submitted)

Vail, D.; Somoza, R.A.; and Caplan, A.I.: MicroRNA Regulation of Human Bone Marrow Derived Mesenchymal Stem Cells in vitro Chondrogenesis: Targeting the Pathway Towards Articular Cartilage Differentiation. Tissue Engineering part A (2021 Oct 25. doi: 10.1089/ten.TEA.2021.0112. Online ahead of print.

Nossin, Y.; Farrell, E.; Koevoet, W.D.; Somoza, R.A.; Caplan, A;I. and Van Osch, G.V.M.: The Releasate of Avascular Cartilage Demonstrates Inherent Pro-Angiogenic Properties In Vitro and In Vivo. Cartilage 2021 13(2_suppl):559S-570S. doi: 10.1177/19476035211047628.

Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: CD146/MCAM Is an Adipogenic Marker for Mesenchymal Stem Cells, Adipose- Derived Stem Cells, and Dermal Fibroblasts.Â Frontiers in Bioengineering and Biotechnology. (submitted)

Bonfield, T.L.; Sutton, M.T.; Fletcher, D.R.; Folz, M.A.; Ragavapura, V.; Somoza, R.A.; and Caplan AI. Donor-defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium. Stem Cells Transl Med. 2021; 1– 15. PMID: 33943038 https://doi.org/10.1002/sctm.20-0521

Caplan, A.I.: Placebo Controls: Now??? Arch Immunol Ther Exp (Warsz) 2021 69(1):9. PMID: 33782781, PMCID: PMC8006883 DOI: 10.1007/s00005-021-00612-x

Zhong, Y.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Glucose Availability Affects Extracellular Matrix Synthesis During Chondrogenesis In Vitro. Tissue Eng Part A. 2021 Jan 26. doi: 10.1089/ten.TEA.2020.0144. Online ahead of print. PMID: 33499734.

Kerr, B.A.; Shi, L.; Jinnah, A.H.; Harris, K.S.; Willey, J.S.; Lennon, D.P.; Caplan, A.I.; and Byzova, T.V.: Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis. Exp Cell Res, 2021 399(2):112456 PMID: 33417921 PMCID: PMC7874523 (available on 2022-02-15) DOI: 10.1016/j.yexcr.2020.112456

Lanzoni, G.; Linetsky, E.; Correa, D.; Messinger Cayetano, S.; Alvarez, R.A.; Kouroupis, D.; Alvarez Gil, A.; Poggioli, R.; Ruiz, P.; Marttos, A.C.; Hirani, K.; Bell, C.A.; Kusack, H.; Rafkin, L.; Baidal, D.; Pastewski, A.; Gawri, K.; Leñero, C.; Mantero, A.M.A.; Metalonis, S.W.; Wang, X.; Roque, L.; Masters, B.; Kenyon, N.S.; Ginzburg, E.; Xu, X.; Tan, J.; Caplan, A.I.; Glassberg, M.K.; Alejandro, R.; and Ricordi, C.: Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. Stem Cells Transl Med. 2021, 10(5):660-673. doi: 10.1002/sctm.20-0472. PMID: 33400390.

Bukulmez, H.; Horkayne-Szakaly, I.; Bilgin, A.; Baker, T.P.; Caplan, A.I.; and Jones, O.Y.: Intrarenal injection of mesenchymal stem cell for treatment of lupus nephritis in mice - a pilot study. Lupus. 2021 Jan;30(1):52-60. doi: 10.1177/0961203320968897. PMID: 33135563

Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20545-20551. doi: 10.1002/anie.202010648. PMID: 32835412

Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print]

Pittenger, M.F.; Discher, D.E.; Péault, B.M.; Phinney, D.G.; Hare, J.M.; and Caplan, A.I.: Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019 4:22. doi: 10.1038/s41536-019-0083-6. eCollection 2019. Review. PMID: 31815001

Vail, D.J.; Somoza, R.A.; Caplan, A.I.; and Khalil, A.M.: Transcriptome Dynamics of Long Non-Coding RNAs and Transcription Factors Demarcate Human Neonatal, Adult, and hMSC-derived Engineered Cartilage. J Tissue Eng Regen Med, 2019 doi: 10.1002/term.2961.

Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Li, M.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation. Tissue engineering. Part A, 25(1-2):80-90, 2019. doi: 10.1089/ten.TEA.2017.0440.

Lennon, D.; Solchaga, L.A.; Somoza, R.A.; Schluchter, M.D.; Margevicius, S.; and Caplan, A.I.: Human and rat bone marrow-derived mesenchymal stem cells differ in their response to fibroblast growth factor and platelet-derived growth factor. Tissue Eng Part A. 2018 Aug 22. doi: 10.1089/ten.TEA.2018.0126. [Epub ahead of print]

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 2018, PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513. [Epub ahead of print]

Vail, D.; Somoza, R.; Caplan, A.; and Khalil, A.: Transcriptome dynamics of long non-coding RNAs and transcription factors demarcate human neonatal, adult, and MSC-derived engineered cartilage. Journal of Tissue Engineering and Regenerative Medicine (Submitted)

Zhong, Y.; Motavalli, M.; Caplan, A.I.; Welter, J.F.; and Baskaran, H.: Dynamics of intrinsic glucose uptake kinetics in human mesenchymal stem cells during chondrogenesis. Annals of Biomedical Engineering, 2018, PMID: 29948374, DOI: 10.1007/s10439-018-2067-x [Epub ahead of print]

Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Chondrogenesis of mesenchymal stem cell related to both -5p and -3p miRNAs. Tissue Eng Part A. 2018 May 24. doi: 10.1089/ten.TEA.2017.0440. [Epub ahead of print] PMID: 29676203

Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. Journal of Orthopaedic Research 36(6):1757-1766. 2018, doi: 10.1002/jor.23820.

Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 doi: 10.1089/ten.TEA.2017.0125. [Epub ahead of print]

Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089/ten.tea.2016.0559.

Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 Aug 21. doi: 10.1089/ten.TEA.2017.0125. [Epub ahead of print]

Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. (Submitted to Journal of Orthopaedic Research).

Mishra, R.; Sefcik, R.S.; Bishop, T.J.; Montelone, S.M.; Crouser, N.; Welter, J.F.; Caplan, A.I.; and Dean, D.: Growth factor dose tuning for bone progenitor cell proliferation and differentiation on resorbable poly(propylene fumarate) scaffolds. Tissue Engineering Part C Methods. 2016 22(9):904-913.

Caplan, A.I.,; Mason, C.; and Reeve, B.: The 3Rs of Cell Therapy. Stem Cells Transl Med. 2016 Aug 8. pii: sctm.2016-0180. [Epub ahead of print]

Tremolada, C.; Ricordi, C.; Caplan, A.I,; and Ventura, C.: Mesenchymal Stem Cells in Lipogems, a Reverse Story: from Clinical Practice to Basic Science.
Methods Mol Biol. 2016;1416:109-22. doi: 10.1007/978-1-4939-3584-0_6.

Shalev-Malul, G.; Soler, D.C.; Ting, A.E.; Lehman, N.A.; Barnboym, E.; McCormick, T.S.; Anthony, D.D.; Lazarus, H.M.; Caplan, A.I.; Breitman, M.; and Singer, N.G.: Development of a functional biomarker for use in cell-based therapy studies in seropositive rheumatoid arthritis. Stem Cells Transl Med. 2016 5(5):628-31.

Sutton, M.T.; Fletcher, D.; Ghosh, S.K.; Weinberg, A.; van Heeckeren, R.; Kaur, S.; Sadeghi, Z.; Hijaz, A.; Reese, J.; Lazarus, H.M.; Lennon, D.P.; Caplan, A.I.; and Bonfield, T.L.: Antimicrobial properties of mesenchymal stem cells: therapeutic potential for cystic fibrosis infection, and treatment. Stem Cells Int. 2016;2016:5303048. doi: 10.1155/2016/5303048. Epub 2016 Jan 26.

Caplan A.I.: MSCs: The sentinel and safe-guards of injury. J Cell Physiol. 2016 231(7):1413-1416.

Barker, N.M.; Carrino, D.A.; Caplan, A.I.; Hurd, W.W.; Liu, J.H.; Tan, H.; and Mesiano S.: Proteoglycans in leiomyoma and normal myometrium: abundance, steroid hormone control, and implications for pathophysiology. Reprod Sci. 2016 23(3):302-9.

Correa D.; Lin, P.; Somoza, R.; Schiemann, W.P.; and Caplan, A.I.: Bone marrow Mesenchymal Stem Cells (BM-MSCs) regulate melanoma cancer cell extravasation at their perivascular niche. International Journal of Cancer, 2016 15;138(2):417-27.

Chung-Chiun Liu

Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; and Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angewandte Chemie International Ed In English, 2020, 59(46):20545-20551. PMID: 32835412

Tsai, J.P.; Jan, Y.T.; Yun, C.H.; Sung, K.T.; Liu, C.C.; Kuo, J.Y.; Hung, C.L.; Wu, T.H.; Lin, J.L.; Hou, C.J.; Yeh, H.I.; Bezerra, H.G.; and So, A.: Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship. PLoS One, 2020, 15(1):e0227680. PMCID: PMC6952096; PMID: 31917812

Xu, W.; Jin, T.; Dai, Y.; and Liu, C.C.: Surpassing the detection limit and accuracy of the electrochemical DNA sensor through the application of CRISPR Cas systems. Biosensors and Bioelectronics, 2020, 155:112100. PMID: 32090878

Ying, Z.; Feng, L.; Ji, D.; Zhang, Y.; Chen, W.; Dai, Y.; Janyasupab, M.; Li, X.; Wen, W.; and Liu, C.C.: Phase-Regulated Sensing Mechanism of MoS(2) Based Nanohybrids toward Point-of-Care Prostate Cancer Diagnosis. Small, 2020, 16(18):e2000307. PMID: 32250065

Dai, Y.; Chiu, L.Y.; Sui, Y.; Dai, Q.; Penumutchu, S.; Jain, N.; Dai, L.; Zorman, C.A.; Tolbert, B.S.; Sankaran, R.M.; and Liu, C.C.: Nanoparticle based simple electrochemical biosensor platform for profiling of protein-nucleic acid interactions. Talanta, 2019, 195:46-54. PMID: 30625570

Dai, Y.; Furst, A.; and Liu, C.C.: Strand Displacement Strategies for Biosensor Applications. Trends in Biotechnology, 2019, 37(12):1367-1382. PMID: 31679827

Dai, Y. and Liu, C.C.: Recent Advances on Electrochemical Biosensing Strategies toward Universal Point-of-Care Systems. Angewandte Chemie International Ed In English, 2019, 58(36):12355-12368. PMID: 30990933

Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angewandte Chemie International Ed In English, 2019, 58(48):17399-17405. PMCID: PMC6938695; PMID: 31568601

Xu, W.; Wang, D.; Li, D.; and Liu, C.C.: Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection. Int J Mol Sci, 2019, 21(1). PMCID: PMC6981776; PMID: 31878197

Xu, X.; Ji, D.; Zhang, Y.; Gao, X.; Xu, P.; Li, X.; Liu, C.C.; and Wen, W.: Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor. ACS Appl Mater Interfaces, 2019, 11(23):20734-20742. PMID: 31094505

Dai, Y.; Abbasi, K.; DePietro, M.; Butler, S.; and Liu, C.C.: Advanced fabrication of biosensor on detection of Glypican-1 using S-Acetylmercaptosuccinic anhydride (SAMSA) modification of antibody. Sci Rep, 2018, 8(1):13541. PMCID: PMC6131508; PMID: 30202003

Dai, Y.; Molazemhosseini, A.; Abbasi, K.; and Liu, C.C.: A Cuprous Oxide Thin Film Non-Enzymatic Glucose Sensor Using Differential Pulse Voltammetry and Other Voltammetry Methods and a Comparison to Different Thin Film Electrodes on the Detection of Glucose in an Alkaline Solution. Biosensors (Basel), 2018, 8(1). PMCID: PMC5872052; PMID: 29316652

Dai, Y.; Wang, C.; Chiu, L.Y.; Abbasi, K.; Tolbert, B.S.; Sauvé, G.; Yen, Y.; and Liu, C.C.: Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43. Biosensors and Bioelectronics, 2018, 117:60-67. PMCID: PMC6082407; PMID: 29885581

Sung, K.T.; Kuo, R.; Sun, J.Y.; Hung, T.C.; Chang, S.C.; Liu, C.C.; Yun, C.H.; Wu, T.H.; Hung, C.L.; Yeh, H.I.; Hou, C.J.; Cury, R.C.; Zidar, D.A.; Bezerra, H.G.; and Longenecker, C.T.: Associations between CT-determined visceral fat burden, hepatic steatosis, circulating white blood cell counts and neutrophil-to-lymphocyte ratio. PLoS One, 2018, 13(11):e0207284. PMCID: PMC6245737; PMID: 30458019

Yao, J.; Wang, Y.; Dai, Y.; and Liu, C.C.: Bioconjugated, Single-Use Biosensor for the Detection of Biomarkers of Prostate Cancer. ACS Omega, 2018, 3(6):6411-6418. PMCID: PMC6044577; PMID: 30023946

Dai, Y. and Liu, C.C.: Detection of 17 β-Estradiol in Environmental Samples and for Health Care Using a Single-Use, Cost-Effective Biosensor Based on Differential Pulse Voltammetry (DPV). Biosensors (Basel), 2017, 7(2). PMCID: PMC5487957; PMID: 28353630

Dai, Y. and Liu, C.C.: A Simple, Cost-Effective Sensor for Detecting Lead Ions in Water Using Under-Potential Deposited Bismuth Sub-Layer with Differential Pulse Voltammetry (DPV). Sensors (Basel), 2017, 17(5). PMCID: PMC5461074; PMID: 28441356

Dai, Y.; Molazemhosseini, A.; and Liu, C.C.: In Vitro Quantified Determination of β-Amyloid 42 Peptides, a Biomarker of Neuro-Degenerative Disorders, in PBS and Human Serum Using a Simple, Cost-Effective Thin Gold Film Biosensor. Biosensors (Basel), 2017, 7(3). PMCID: PMC5618035; PMID: 28726727

Dai, Y.; Molazemhosseini, A.; and Liu, C.C.: A Single-Use, In Vitro Biosensor for the Detection of T-Tau Protein, A Biomarker of Neuro-Degenerative Disorders, in PBS and Human Serum Using Differential Pulse Voltammetry (DPV). Biosensors (Basel), 2017, 7(1). PMCID: PMC5371783; PMID: 28218731

Molazemhosseini, A.; Magagnin, L.; Vena, P.; and Liu, C.C.: Single-Use Disposable Electrochemical Label-Free Immunosensor for Detection of Glycated Hemoglobin (HbA1c) Using Differential Pulse Voltammetry (DPV). Sensors (Basel), 2016, 16(7). PMCID: PMC4970074; PMID: 27376299

Yun, C.H.; Longenecker, C.T.; Chang, H.R.; Mok, G.S.; Sun, J.Y.; Liu, C.C.; Kuo, J.Y.; Hung, C.L.; Wu, T.H.; Yeh, H.I.; Yang, F.S.; Lee, J.J.; Hou, C.J.; Cury, R.C.; and Bezerra, H.G.: The association among peri-aortic root adipose tissue, metabolic derangements and burden of atherosclerosis in asymptomatic population. J Cardiovasc Comput Tomogr, 2016, 10(1):44-51. PMID: 26507645

Joseph M. Mansour

Kumar, D.; Moore, R.M.; Mercer, B.M.; Mansour, J.M.; and Moore, J.J.: Mechanism of human fetal membrane biomechanical weakening, rupture and potential targets for therapeutic intervention. Obstet Gynecol Clin North Am. 2020 47(4):523-544. doi: 10.1016/j.ogc.2020.08.010. PMID: 33121643

Mansour, J.M.; Motavalli, M.; Bensusan, J.; Li, M.; Margevicius, S.; and Welter, J.F.: The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling. J Mech Behav Biomed Mater. 2020 Oct;110:103923. doi: 10.1016/j.jmbbm.2020.103923. PMID: 32952604

Motavalli, M.; Jones, C.; Berilla, J.A.; Li, M.; Schluchter, M.D.; Mansour, J.M.; and Welter, J.F.: Apparatus and method for rapid detection of acoustic anisotropy in cartilage. Journal of Medical and Biological Engineering, 2020, 40:419–427.

Sharma, A.; Kumar, D.; Moore, R.M.; Deshmukh, A.; Mercer, B.M.; Mansour, J.M.; and Moore, J.J.: Granulocyte macrophage colony stimulating factor (GM-CSF), the critical intermediate of inflammation-induced fetal membrane weakening, primarily exerts its weakening effect on the choriodecidua rather than the amnion. Placenta. 2020 89:1-7. doi: 10.1016/j.placenta.2019.10.003. PMID: 31665659

Kumar, D.; Moore, R.M.; Sharma, A.; Mercer, B.M.; Mansour, J.M.;and Moore, J.J.: In an in-vitro model using human fetal membranes, α-lipoic acid inhibits inflammation induced fetal membrane weakening. Placenta. 2018 68:9-14. doi: 10.1016/j.placenta.2018.06.305. PMID: 30055672

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 2018, 24(8):443-456 PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513.

Whitney, G.A.; Kean, T.J.: Fernandes, R.J.; Waldman, S.; Tse, M.Y.; Pang, S.C.; Mansour, J.M.; and Dennis, J.E.: Thyroxine increases collagen type II expression and accumulation in scaffold-free tissue-engineered articular cartilage. Tissue Eng Part A. 2017 doi: 10.1089/ten.TEA.2016.0533. [Epub ahead of print]

Kumar, D.; Moore, R.M.; Mercer, B.M.; Mansour, J.M.; Redline, R.W.; and Moore, J.J.: The physiology of fetal membrane weakening and rupture: Insights gained from the determination of physical properties revisited. Placenta. 2016, 42:59-73. doi: 10.1016/j.placenta.2016.03.015.

Zhou,H.; Gawlik, A.; Hernandez, C.; Goss, M.; Mansour,J.; and Exner, A.: Nondestructive characterization of biodegradable polymer erosion in vivo using ultrasound elastography imaging ACS Biomater. Sci. Eng. 2016 (Accepted)

Mansour, J.; Lee, Z.; and Welter, J.: Nondestructive techniques to evaluate the characteristics and development of engineered cartilage. (Invited review). Annals of Biomedical Engineering. 2016 44(3):733-749.

Zhou, H.; Goss, M.; Hernandez, C.; Mansour, J.M.; and Exner, A.: Validation of ultrasound elastography imaging for nondestructive characterization of stiffer biomaterials. Annals of Biomedical Engineering. 2016 44(5):1515-1523.

Seunghee Margevicius

Lipinski, J.; Margevicius, S.; Schluchter, M.D.; Wilson, D.L.; McComsey, G.A.; and Longenecker, C.T.: Statin effect on coronary calcium distribution, mass and volume scores and associations with immune activation among HIV+ persons on antiretroviral therapy. Antivir Ther. 2021 Apr 26. doi: 10.3851/IMP3389. PMID: 33901017. Online ahead of print.

Cummings, L.C.; Kou, T.D.; Chak, A.; Schluchter, M.D.; Margevicius, S.; and Cooper, G.S.: Receipt of serial endoscopy procedures prior to esophageal adenocarcinoma diagnosis is associated with better survival. Dig Dis Sci. 2021 Apr 21. doi: 10.1007/s10620-021-06927-1. PMID: 33881677. Online ahead of print.

Owusu, C.; Nock, N.L.; Feuntes, V.; Margevicius, S.; Hergenroeder, P.; Austin, K.; Bennet, E.; Cerne, S.; Moore, H.C.F.; Petkac, J.; Schluchter, M.; Schmitz, K.H.; Webb Hooper, M.; Coccia, S.; Nagy, C.; Wimbley, L.; and Berger, N.A.: IMPROVE, a community-based exercise intervention versus support group to improve functional and health outcomes among older African American and Non-Hispanic White breast cancer survivors from diverse socioeconomic backgrounds: Recruitment strategies and baseline characteristics. Cancer, 2021. PMID: 33539554

Peters, M.; Margevicius, S.; Kityo, C.; Mirembe, G.; Buggey, J.; Brinza, E.; Schluchter, M.; Yun, C.H.; Hung, C.L.; McComsey, G.A.; and Longenecker, C.T.: Association of Kidney Disease With Abnormal Cardiac Structure and Function Among Ugandans With HIV Infection. Journal of Acquired Immune Deficiency Syndromes, 2021, 86(1):104-109. PMID: 33044321

Hamilton, J.I.; Pahwa, S.; Adedigba, J.; Frankel, S.; O'Connor, G.; Thomas, R.; Walker, J.R.; Killinc, O.; Lo, W.C.; Batesole, J.; Margevicius, S.; Griswold, M.; Rajagopalan, S.; Gulani, V.; and Seiberlich, N.: Simultaneous Mapping of T(1) and T(2) Using Cardiac Magnetic Resonance Fingerprinting in a Cohort of Healthy Subjects at 1.5T. Journal of Magnetic Resonance Imaging, 2020, 52(4):1044-1052. PMCID: PMC7772954; PMID: 32222092

Still, C.H.; Margevicius, S.; Harwell, C.; Huang, M.C.; Martin, L.; Dang, P.B.; and Wright Jnr, J.T.: A Community and Technology-Based Approach for Hypertension Self-Management (COACHMAN) to Improve Blood Pressure Control in African Americans: Results from a Pilot Study. Patient Prefer Adherence, 2020, 14:2301-2313. PMCID: PMC7695598; PMID: 33262580

Surdam, J.; Daly, B.; Fulton, S.; Margevicius, S.; Schluchter, M.; Flocke, S.; Manne, S.; and Meropol, N.J.: Recruitment Strategies for Nurse Enrollment in an Online Study. Nursing Research, 2020, 69(1):69-73. PMCID: PMC6911026; PMID: 31804433

Cummings Iii, K.C.; Kou, T.D.; Chak, A.; Schluchter, M.D.; Margevicius, S.; Cooper, G.S.; Meropol, N.J.; Perry, Y.; Linden, P.A.; and Cummings, L.C.: Surgical approach and the impact of epidural analgesia on survival after esophagectomy for cancer: A population-based retrospective cohort study. PLoS One, 2019, 14(1):e0211125. PMCID: PMC6342325; PMID: 30668599

Flocke, S.A.; Nock, N.L.; Fulton, S.; Margevicius, S.; Manne, S.; Meropol, N.J.; and Daly, B.J.: A National Study of Oncology Nurses Discussing Cancer Clinical Trials With Patients. Western Journal of Nursing Research, 2019, 41(12):1747-1760. PMCID: PMC6699918; PMID: 30782111

Panda, A.; Obmann, V.C.; Lo, W.C.; Margevicius, S.; Jiang, Y.; Schluchter, M.; Patel, I.J.; Nakamoto, D.; Badve, C.; Griswold, M.A.; Jaeger, I.; Ponsky, L.E.; and Gulani, V.: MR Fingerprinting and ADC Mapping for Characterization of Lesions in the Transition Zone of the Prostate Gland. Radiology, 2019, 292(3):685-694. PMCID: PMC6716564; PMID: 31335285

Panda, A.; OʼConnor, G.; Lo, W.C.; Jiang, Y.; Margevicius, S.; Schluchter, M.; Ponsky, L.E.; and Gulani, V.: Targeted Biopsy Validation of Peripheral Zone Prostate Cancer Characterization With Magnetic Resonance Fingerprinting and Diffusion Mapping. Investigative Radiology, 2019, 54(8):485-493. PMCID: PMC6602844; PMID: 30985480

Babcook, M.A.; Akgul, M.; Margevicius, S.; MacLennan, G.T.; Fu, P.; Abouassaly, R.; and Gupta, S.: Ser-486/491 phosphorylation and inhibition of AMPKα activity is positively associated with Gleason score, metastasis, and castration-resistance in prostate cancer: A retrospective clinical study. Prostate, 2018, 78(10):714-723. PMCID: PMC6591712; PMID: 29577356

Lennon, D.; Solchaga, L.A.; Somoza, R.A.; Schluchter, M.D.; Margevicius, S.; and Caplan, A.I.: Human and Rat Bone Marrow-Derived Mesenchymal Stem Cells Differ in Their Response to Fibroblast Growth Factor and Platelet-Derived Growth Factor. Tissue Eng Part A, 2018, 24(23-24):1831-1843. PMCID: PMC6302675; PMID: 29936884

Rodgers-Melnick, S.N.; Matthie, N.; Jenerette, C.; Griest Pell, T.J.; Lane, D.; Fu, P.; Margevicius, S.; and Little, J.A.: The Effects of a Single Electronic Music Improvisation Session on the Pain of Adults with Sickle Cell Disease: A Mixed Methods Pilot Study. J Music Ther, 2018, 55(2):156-185. PMID: 29796596

Badve, C.; Yu, A.; Dastmalchian, S.; Rogers, M.; Ma, D.; Jiang, Y.; Margevicius, S.; Pahwa, S.; Lu, Z.; Schluchter, M.; Sunshine, J.; Griswold, M.; Sloan, A.; and Gulani, V.: MR Fingerprinting of Adult Brain Tumors: Initial Experience. AJNR American Journal of Neuroradiology, 2017, 38(3):492-499. PMCID: PMC5352493; PMID: 28034994

Longenecker, C.T.; Margevicius, S.; Liu, Y.; Schluchter, M.D.; Yun, C.H.; Bezerra, H.G.; and McComsey, G.A.: Effect of Pericardial Fat Volume and Density on Markers of Insulin Resistance and Inflammation in Patients With Human Immunodeficiency Virus Infection. American Journal of Cardiology, 2017, 120(8):1427-1433. PMCID: PMC5614847; PMID: 28822563

Owusu, C.; Margevicius, S.; Schluchter, M.; Koroukian, S.M.; and Berger, N.A.: Short Physical Performance Battery, usual gait speed, grip strength and Vulnerable Elders Survey each predict functional decline among older women with breast cancer. J Geriatr Oncol, 2017, 8(5):356-362. PMCID: PMC5747299; PMID: 28743505

Rodgers-Melnick, S.N.; Pell, T.J.G.; Lane, D.; Jenerette, C.; Fu, P.; Margevicius, S.; and Little, J.A.: The effects of music therapy on transition outcomes in adolescents and young adults with sickle cell disease. Int J Adolesc Med Health, 2017, 31(3). PMID: 28779565

Yu, A.C.; Badve, C.; Ponsky, L.E.; Pahwa, S.; Dastmalchian, S.; Rogers, M.; Jiang, Y.; Margevicius, S.; Schluchter, M.; Tabayoyong, W.; Abouassaly, R.; McGivney, D.; Griswold, M.A.; and Gulani, V.: Development of a Combined MR Fingerprinting and Diffusion Examination for Prostate Cancer. Radiology, 2017, 283(3):729-738. PMCID: PMC5452885; PMID: 28187264

Meropol, N.J.; Wong, Y.N.; Albrecht, T.; Manne, S.; Miller, S.M.; Flamm, A.L.; Benson, A.B., 3rd; Buzaglo, J.; Collins, M.; Egleston, B.; Fleisher, L.; Katz, M.; Kinzy, T.G.; Liu, T.M.; Margevicius, S.; Miller, D.M.; Poole, D.; Roach, N.; Ross, E.; and Schluchter, M.D.: Randomized Trial of a Web-Based Intervention to Address Barriers to Clinical Trials. Journal of Clinical Oncology, 2016, 34(5):469-478. PMCID: PMC4872012 online at www.jco.org. Author contributions are found at the end of this article.; PMID: 26700123

Owusu, C.; Margevicius, S.; Schluchter, M.; Koroukian, S.M.; Schmitz, K.H.; and Berger, N.A.: Vulnerable elders survey and socioeconomic status predict functional decline and death among older women with newly diagnosed nonmetastatic breast cancer. Cancer, 2016, 122(16):2579-2586. PMCID: PMC5027843; PMID: 27348765

Wong, Y.N.; Schluchter, M.D.; Albrecht, T.L.; Benson, A.B., 3rd; Buzaglo, J.; Collins, M.; Flamm, A.L.; Fleisher, L.; Katz, M.; Kinzy, T.G.; Liu, T.M.; Manne, S.; Margevicius, S.; Miller, D.M.; Miller, S.M.; Poole, D.; Raivitch, S.; Roach, N.; Ross, E.; and Meropol, N.J.: Financial Concerns About Participation in Clinical Trials Among Patients With Cancer. Journal of Clinical Oncology, 2016, 34(5):479-487. PMCID: PMC4872013 online at www.jco.org. Author contributions are found at the end of this article.; PMID: 26700120

Mary Clare McCorry

Boys, A.J.; Zhou, H.; Harrod, J.B.; McCorry, M.C.; Estroff, L.A.; and Bonassar, L.J.: Top-down Fabrication of Spatially Controlled Mineral-Gradient Scaffolds for Interfacial Tissue Engineering. ACS Biomater Sci Eng, 2019, 5(6):2988-2997. PMCID: PMC6574130; PMID: 31211246

Iannucci, L.E.; Boys, A.J.; McCorry, M.C.; Estroff, L.A.; and Bonassar, L.J.: Cellular and Chemical Gradients to Engineer the Meniscus-to-Bone Insertion. Adv Healthc Mater, 2019, 8(7):e1800806. PMCID: PMC6458090; PMID: 30536862

McCorry, M.C.; Kim, J.; Springer, N.L.; Sandy, J.; Plaas, A.; and Bonassar, L.J.: Regulation of proteoglycan production by varying glucose concentrations controls fiber formation in tissue engineered menisci. Acta Biomaterialia, 2019, 100:173-183. PMID: 31546030

Boys, A.J.; McCorry, M.C.; Rodeo, S.; Bonassar, L.J.; and Estroff, L.A.: Next Generation Tissue Engineering of Orthopedic Soft Tissue-to-Bone Interfaces. MRS Commun, 2017, 7(3):289-308. PMCID: PMC5761353; PMID: 29333332

Kaymakcalan, O.E.; Jin, J.L.; Sun, Z.; Ricapito, N.G.; McCorry, M.C.; Morrison, K.A.; Putnam, D.; and Spector, J.A.: Transient phase behavior of an elastomeric biomaterial applied to abdominal laparotomy closure. Acta Biomaterialia, 2017, 58:413-420. PMID: 28576717

McCorry, M.C. and Bonassar, L.J.: Fiber development and matrix production in tissue-engineered menisci using bovine mesenchymal stem cells and fibrochondrocytes. Connective Tissue Research, 2017, 58(3-4):329-341. PMCID: PMC5709035; PMID: 27925474

McCorry, M.C.; Mansfield, M.M.; Sha, X.; Coppola, D.J.; Lee, J.W.; and Bonassar, L.J.: A model system for developing a tissue engineered meniscal enthesis. Acta Biomaterialia, 2017, 56:110-117. PMCID: PMC7326006; PMID: 27989921

McCorry, M.C.; Puetzer, J.L.; and Bonassar, L.J.: Characterization of mesenchymal stem cells and fibrochondrocytes in three-dimensional co-culture: analysis of cell shape, matrix production, and mechanical performance. Stem Cell Res Ther, 2016, 7:39. PMCID: PMC4789279; PMID: 26971202

Richard McFarland

Lin-Gibson, S.; Lin, N.J.; Jackson, S.; Viswanathan, S.; Zylberberg, C.; Wolfrum, J.; Basu, S.; Roy, K.; Marshall. D.; McFarland, R.; Hoover, S.; Rietze, R.; Getz, A.; and Henke, D.: Standards efforts and landscape for rapid microbial testing methodologies in regenerative medicine. Cytotherapy. 2021 May;23(5):390-398. doi: 10.1016/j.jcyt.2020.07.006. PMID: 33775524

Tsokas, K.; McFarland, R.; Burke, C.; Lynch, J.L.; Bollenbach, T.; Callaway Ii, D.A.; and Siegel, J.: Reducing Risks and Delays in the Translation of Cell and Gene Therapy Innovations into Regulated Products. NAM Perspectives, 2019.

Haddock, R.; Lin-Gibson, S.; Lumelsky, N.; McFarland, R.; Roy, K.; Saha, K.; Zhang, J.; and Zylberberg, C. Manufacturing cell therapies: The paradigm shift in health care of this century. . NAM Perspectives; Washington, DC: National Academy of Medicine; 2017.

Witten, C.M.; McFarland, R.D.; and Simek, S.L.: Concise Review: The U.S. Food and Drug Administration and Regenerative Medicine. Stem Cells Transl Med, 2015, 4(12):1495-1499. PMCID: PMC4675507; PMID: 26494784

Mostafa Motavalli

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 2018, 24(8):443-456 PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513.

Rodrigo Somoza

Sorrel, J.M.; Somoza, R.A.; Baber, M.A.; Kenyon. J.; and Caplan. A.I.: Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells During Wound Healing. Cells. (submitted)

Nossin, Y.; Farrell, E.; Koevoet, W.D.; Somoza, R.A.; Caplan, A;I. and Van Osch, G.V.M.: Cartilage has a pro-angiogenic releasate. Cartilage (submitted)

Somoza, R.A. and Welter, J.F.: Isolation of Chondrocytes from Human Cartilage and Cultures in Monolayer and 3D. Methods Mol Biol. 2021;2245:1-12. doi: 10.1007/978-1-0716-1119-7_1. PMID: 33315191

Lennon, D.P.; Somoza, R.A.; Schluchter, M.A.; and Caplan, A.I.: The Habitat Assay, a Platform to Study In Vivo Properties of Human Mesenchymal Stem Cells. Tissue Eng Part A. 2020 26(23-24):1378-1387. PMID: 33107389 PMCID: PMC7759284 (available on 2021-12-01) DOI: 10.1089/ten.TEA.2020.0178

Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation. Tissue Engineering 25(1-2):80-90, 2019. doi: 10.1089/ten.TEA.2017.0440.

Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Human mesenchymal stem cells (MSCs) do not make articular cartilage in vitro: Transcriptome-wide analyses of human neonatal cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering 2017 (Submitted)

Correa D.; Somoza, R.; Lin, P.; Schiemann, W.P.; and Caplan, A.I.: Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche. International Journal of Cancer 2016 138(2):417-27

Jean F. Welter

Jung, H.; Mclellan, P.; Welter, J.F.; and Akkus, O.: Chondrogenesis Mesenchymal Stem Cells via Local Release of TGFβ3 from Heparinized Collagen Biofabric. Tissue Eng Part A. 2021 Nov;27(21-22):1434-1445. DOI: 10.1089/ten.TEA.2020.0383. PMID: 33827271

Somoza, R.A. and Welter, J.F.: Isolation of Chondrocytes from Human Cartilage and Cultures in Monolayer and 3D. Methods Mol Biol. 2021;2245:1-12. doi: 10.1007/978-1-0716-1119-7_1. PMID: 33315191

Larson, B.L.; Yu, S.N.; Park, H.; Estes, B.T.; Moutos, F.T.; Bloomquist, C.J.; Wu, P.B.; Welter, J.F.; Langer, R.; Guilak, F.; and Freed, L.E.: Cartilaginous and osteochondral tissue formation by human mesenchymal stem cells on three-dimensionally woven scaffolds. Journal of Tissue Engineering and Regenerative Medicine. 2019 doi: 10.1002/anie.2019107722019

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Kean, T.J.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. Tissue engineering, part C, 24(8):443-456, 2018, PMID: 29999475, doi: 10.1089/ten.TEC.2017.0513.

Wang, K-C.; Egelhoff, T.T.; Caplan, A.I.; Welter, J.F.; Baskaran, H.: ROCK Inhibition promotes development of chondrogenic tissue by improved mass transport, Tissue Engineering Part A, 2018, PMID: 29397789, DOI: 10.1089/ten.TEA.2017.0438 (Epub ahead of print)</p
Verbus, E.A.; Kenyon, J.D.; Sergeeva, O.; Awadallah, A.; Yuan, L.; Welter, J.F.; Caplan, A.I.; Schluchter, M.D.; Khalil, A.M.; and Lee, Z.: Expression of miR-145-5p during chondrogenesis of mesenchymal stem cells 2017 (Submitted to Stem Cells and Translational Medicine)

Mansour, J.M.; Motavalli, M.; Dennis, J.E.; Caplan, A.I.; Berilla, J.A.; and Welter, J.F.: Rapid detection of shear-induced damage in tissue engineered cartilage using ultrasound. (Submitted)