Interests: Cartilage Tissue Engineering, Somatic Stem Cell Biology, Reprogramming Technology (IPS), Cell Therapy and Tissue Regeneration, Cancer Metastasis.
Publications
Somoza, R.A. and Welter, J.F.: Isolation of Chondrocytes from Human Cartilage and Cultures in Monolayer and 3D. Methods Mol Biol. 2021;2245:1-12. doi: 10.1007/978-1-0716-1119-7_1. PMID: 33315191
Dai, Y.; Xu, W.; Somoza, R.A.; Welter, J.F.; Caplan, A.I.; Liu, C.C.: An Integrated Multi-Function Heterogeneous Biochemical Circuit for High-Resolution Electrochemistry-Based Genetic Analysis. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20545-20551. doi: 10.1002/anie.202010648. PMID: 32835412
Dai, Y.; Somoza, R.A.; Wang, L.; Welter, J.F.; Li, Y.; Caplan, A.I.; and Liu, C.C.: Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. Angew Chem Int Ed Engl. 2019 Sep 30. doi: 10.1002/anie.201910772. [Epub ahead of print]
Vail, D.J.; Somoza, R.A.; Caplan, A.I.; and Khalil, A.M.: Transcriptome Dynamics of Long Non-Coding RNAs and Transcription Factors Demarcate Human Neonatal, Adult, and hMSC-derived Engineered Cartilage. J Tissue Eng Regen Med, 2019 doi: 10.1002/term.2961. [Epub ahead of print]
Kenyon, J.D.; Sergeeva, O.; Somoza, R.A.; Caplan, A.I.; Khalil, A.M.; and Lee, Z.: Analysis of -5p and -3p Strands of miR-145 and miR-140 During Mesenchymal Stem Cell Chondrogenic Differentiation. Tissue Engineering 25(1-2):80-90, 2019. doi: 10.1089/ten.TEA.2017.0440.
Sorrell, J.M.; Somoza, R.A.; and Caplan, A.I.: Human mesenchymal stem cells induced to differentiate as chondrocytes follow a biphasic pattern of extracellular matrix production. Journal of Orthopaedic Research 36(6):1757-1766. 2018, doi: 10.1002/jor.23820 Abstract
Correa, D.; Somoza, R.A.; and Caplan, A.I.: Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis. Tissue Eng Part A. 2017 doi: 10.1089/ten.TEA.2017.0125. [Epub ahead of print]
Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Transcriptome-wide analyses of human neonatal articular cartilage and human mesenchymal stem cell-derived cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering, Part A, DOI: 10.1089/ten.tea.2016.0559
Somoza, R.A.; Correa, D.; Labat, I.; Sternberg, H.; Forrest, M.E.; Khalil, A.M.; West, M.D.; Tesar, P.; and Caplan, A.I.: Human mesenchymal stem cells (MSCs) do not make articular cartilage in vitro: Transcriptome-wide analyses of human neonatal cartilage provide a new molecular target for evaluating engineered cartilage. Tissue Engineering 2017 (Submitted)
Correa D.; Somoza, R.; Lin, P.; Schiemann, W.P.; and Caplan, A.I.: Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche. International Journal of Cancer 2016 138(2):417-27