1. Home
  2. Publications

Publications

The researchers of Acharya Lab at Case Western Reserve University focus on drug delivery materials, biomaterial development, metabolite delivery, mitochondrial biology and more. Discover our publications, patents and startup companies below. 

View Our Publications on PubMed

Published Peer-Review Journal Articles Key

Symbol Peer Type
* Corresponding
Bold PhD
# Masters
+ Equal contribution
‡ Highschool
∞ Volunteer
_ Undergraduate
= Postdoc

Publications 

Assistant Professor, Case Western Reserve University (2023–Present)

  1. Inamdar S+, Suresh AP+, Mangal JL, _Ng ND, _Sundem A, =Wu C, Lintecum     K, Thumsi A, Khodaei T, #Halim M, =Appel N, =Jaggarapu MMCS, Esrafili A, Curtis M, Acharya AP*, “Rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice” Nature Communications, 14, 5333, 2023. Source Data for Sahil et al. Nature Communications 2023. 

Assistant Professor, Arizona State University (2019–2023)

  1.  Inamdar S, Suresh AP, Mangal JL, _Ng ND, _Sundem A, Behbahani HS, =Rubino Jr. TE, Yaron JR, Khodaei T, Green M, Curtis M, Acharya AP*, “Succinate in the tumor microenvironment affects tumor growth and modulates tumor associated macrophages”, Biomaterials, 2023.
  2. Inamdar S, Suresh AP, Mangal JL, _Ng ND, _Sundem A, Behbahani HS, =Rubino Jr. TE, =Shi X, =Loa ST, Yaron JR, Hitosugi T, Green M, Gu H, Curtis M, Acharya AP*, “Succinate based polymers drive immunometabolism in dendritic cells to generate cancer immunotherapy”, Journal of Controlled Release, 2023.
  3. =Y Yan, Y Zhao, Y Lu, AP Acharya, W Wang, CG Zhan, J Ye, F Du, X Zhu, Y Xu*, “Characterization of two novel phosphodiesterase 2 inhibitors Hcyb1 and PF-05180999 on depression-and anxiety-like behavior”, International Journal of Neuropsychopharmacology, pyad020, 2023.
  4. T Khodaei, _E Schmitzer, AP Suresh, AP Acharya *, “Immune response differences in degradable and non-degradable alloy implants”, Bioactive Materials 24, 153-170, 2023.
  5. A Thumsi, _SJ Swaminathan, JL Mangal, AP Suresh, AP Acharya*, “Vaccines prevent reinduction of rheumatoid arthritis symptoms in collagen-induced arthritis mouse model”, Drug Delivery and Translational Research, 1-11, 2023.
  6. MMCS Jaggarapu=, D Ghosh, _T Johnston, JR Yaron=, JL Mangal, S Inamdar, M Gosangi=, K Rege, AP Acharya*, “Alpha‐ketoglutaric acid based polymeric particles for cutaneous wound healing”, Journal of Biomedical Materials Research Part A, 2023.
  7. AP Acharya=*, KB Sezginel, HP Gideon =, AC Greene, HD Lawson, S Inamdar, Y Tang =, _AJ Fraser, _KV Patel, C Liu =, NL Rosi, SY Chan, JL Flynn, CE Wilmer, SR Little * “In silico identification and synthesis of a multi-drug loaded MOF for treating tuberculosis”, J Control Release, Oct 25;352:242-255, 2022.
  8. Inamdar S, Tylek T=, Suresh AP, _Ng ND, _Schmitzer E, Lintecum K, Ávila C=, Fryer JD, Xu Y, Spiller KL, Acharya AP* “Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models”, Biomaterials, 293, 121973, 2022.
  9. JL Mangal, S Inamdar, AP Suresh, MMCS Jaggarapu =, A Esrafili, _ND Ng, AP Acharya*, “Short Term, Low Dose Alpha-ketoglutarate Based Polymeric Nanoparticles with Methotrexate Reverse Rheumatoid Arthritis Symptoms in Mice and Modulate T Helper Cell Responses”, Biomaterials Science, 2022.
  10. T Khodaei∞, S Inamdar, AP Suresh, AP Acharya*, “Drug delivery of metabolism targeted cancer immunotherapy”, Advanced Drug Delivery Reviews, 114242, 2022.
  11. T Le#, B Aguilar, JL Mangal, Acharya AP*, “Oral drug delivery for immunoengineering” Bioengineering & Translational Medicine 7 (1), e10243, 2021.
  12. JL Mangal, Basu N‡, Wu HJ, Acharya AP*, “Immunometabolism: An Emerging Target for Immunotherapies to Treat Rheumatoid Arthritis” Immunometabolism 2021, 3(4):e210032.
  13. JL Mangal, Inamdar S, Le T, Shi X, Curtis M, Gu H, Acharya AP*, “Inhibition of glycolysis in the presence of antigen generates suppressive antigen-specific responses and restrains rheumatoid arthritis in mice”, Biomaterials, 2021 Aug 20;277:121079.
  14. R Raja, C Wu, F Limbeck, K Butler, AP Acharya, M Curtis, “Instruction of Immunometabolism by Adipose Tissue: Implications for Cancer Progression”, Cancers 13 (13), 3327, 2021.
  15. JL Mangal, JL Handlos#, A Esrafili∞, S Inamdar, S Mcmillian, M Wankhede, Gottardi R, Acharya AP*, “Engineering Metabolism of Chimeric Antigen Receptor (CAR) Cells for Developing Efficient Immunotherapies”, Cancers 13 (5), 1123, 2021.
  16. A Esrafili∞, A Wagner#, S Inamdar, AP Acharya*, “Covalent Organic Frameworks for Biomedical Applications”, Advanced Healthcare Materials, 2002090, 2021.
  17. AP Acharya=, Tang Y, Bertero T, Tai YY, Harvey LD, Woodcock CC, Sun W, Pineda R, Mitash N, Königshoff M, Little SR, Chan SY. "Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension" Journal of the American Heart Association  2021 May 29;e019091.
  18. MR Carstens, Wasserfall CH, Acharya AP, Lewis J, Agrawal N, Koenders K, Bracho-Sanchez E and Keselowsky BG* “GRAS-Microparticle Microarrays Identify Dendritic Cell Tolerogenic Marker-Inducing Formulations”, Lab on a Chip, 2021.
  19. JL Mangal+, S Inamdar+, Yang Y, Dutta S, Wankhede M, Shi X, Gu H, Green M, Rege K, Curtis M, Acharya AP*. “Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism.” J Mater Chem B. 2020 May 19. + - Equal contribution.
  20. AC Greene, AP Acharya=, SB Lee, R Gottardi, E Zaleski, SR Little. “Cranberry extract-based formulations for preventing bacterial biofilms”. Drug Delivery and Translational Research, 11 August 2020.
  21. JD Fisher, W Zhang, SC Balmert, AM Aral, Y Kulahci, AP Acharya=, J Li, HR Turnquist, AW Thomson, MG Solari, VS Gorantla, SR Little*. “Recruitment of Regulatory T Cells Promotes Donor-Specific Tolerance in Vascularized Composite Allotransplantation.” Americal Journal of Transplantation 20, 536-536, 2020
  22. JD Fisher, Zhang W, Balmert SC, Aral AM, Acharya AP=, Kulahci Y, Li J, Turnquist HR, Thomson AW, Solari MG, Gorantla VS, Little SR*, “In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation”. Science Advances, 13 Mar 2020, Vol. 6, no. 11, eaax8429.
  23. X Ding, Gao J, Acharya AP=, Wu Y; Little SR, Wang Y*, “An azido-functionalized polyurethane designed for making tunable elastomers by click chemistry”, ACS Biomaterials Science & Engineering. 2019 2020, 6, 2, 852-864.
  24. JD Fisher, Balmert SC, Zhang W, Schweizer R, Schnider J, Komatsu C, Dong L, Erbas V, Unadkat JV, Aral AM, Acharya AP=, Kulahci Y, Turnquist H, Thomson AW, Solari MG, Gorantla VS, Little SR*, “Treg Inducing Microparticles Promote Donor-Specific Tolerance in Experimental Vascularized Composite Allotransplantation”, PNAS. 2019 Dec 2. pii: 201910701.
  25.  _N Joseph, _Lawson HD, Overholt KJ, Damodaran K, Gottardi R, Acharya AP*, Little SR*., “Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications.” Sci Rep. 2019 Sep 10;9(1):13024.
  26. Gesù R Di, Acharya AP, Jacobs I, Gottardi R. “3D printing for tissue engineering in otolaryngology.” Connect Tissue Res. 2019 Sep 16:1-20.

Postdoctoral Fellow, University of Pittsburgh, Pittsburgh (2014–2018)

  1. TW Fuller#, AP Acharya#, T Meyyappan, M Yu, G Bhaskar, SR Little, TV Tarin, “Comparison of Bladder Carcinogens in the Urine of E-cigarette Users Versus Non E-cigarette Using Controls”, Scientific reports, 2018, 8 (1), 507. * - Equal Contributions.
  2. MP Hwang, X Ding, J Gao, AP Acharya, SR Little, Y Wang, “A biocompatible betaine-functionalized polycation for coacervation”, Soft Matter, 2018,14, 387-395.
  3. ML Ratay, SC Balmert, AP Acharya, AC Greene, T Meyyappan, SR Little, “TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model”, Scientific reports, 2017, 7 (1), 17527
  4. AP Acharya, KM Theisen, A Correa, T Meyyappan, A Apfel, T Sun, TV Tarin, SR Little, “An inexpensive, point-of-care urine test for bladder cancer in patients undergoing hematuria evaluation”, Advanced Healthcare Materials, 2017 Nov;6(22)
  5. Ratay ML, Glowacki AJ, Balmert SC, Acharya AP, Polat J, Andrews LP, Fedorchak MV, Schuman JS, Vignali DAA, Little SR., “Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease.”, Journal of Controlled Release. 2017 Jul 28;258:208-217.
  6. AP Acharya, M Sinha, ML Ratay, X Ding, SC Balmert, CJ Workman, Y Wang, DAA Vignali, SR Little        “Localized Multi-Component Delivery Platform Generates Local and Systemic Anti-Tumor Immunity.”, Advanced Functional Materials, 2017, 27, 366.
  7. JD Fisher, Acharya AP, Little SR, “Micro and nanoparticle drug delivery systems for preventing allotransplant rejection.”, Clinical Immunology, 160, 1, 24–35, 2015.
  8. Acharya AP, Little SR, “Stapled endosome disrupting alginate particles for cytosolic delivery of cations.”, Journal of Drug Targeting – In honor of Prof. Bob Langer, 23 (7-8), 690-697, 2015.

Postdoctoral Fellow, University of California, Berkeley (2011–2014)

  1. Acharya AP, P Sen, K Aran, AB Gardner, M Rafi, D Dean, N Murthy., “A turn‐off fluorescent substrate for horseradish peroxidase improves the sensitivity of ELISAs.”, Journal of Polymer Science Part A: Polymer Chemistry – In honor of Prof. Jean M.J. Fréchet, 53 (2), 206-210, 2015.
  2. Aran K, Parades J, Rafi M, Yau JF, Acharya AP, Zibinsky M, Liepmann D, Murthy N., “Stimuli-responsive electrodes detect oxidative stress and liver injury.”  Advanced Materials. 2015 Feb 25;27(8):1433-6
  3. Acharya AP, Rafi M, Woods EC, Gardner AB, Murthy N, “Metabolic engineering of lactate dehydrogenase rescues mice from acidosis.” Sci Rep. 2014 Jun 5;4:5189.
  4. Acharya AP, Nafisi P, Gardner A, MacKay J, Kundu K, Kumar S, Murthy N, “A fluorescent peroxidase probe increases the sensitivity of ELISAs by 2 orders of magnitude.” 49 (88), 10379-10381– ChemComm, 2013.
  5. AB Gardner, SKC Lee, EC Woods, AP Acharya*, “Biomaterials-Based Modulation of the Immune System”, BioMed research international 2013.
  6. Dasari M, Acharya AP, Kim D, Lee S, Lee S, Rhea J, Molinaro R., Murthy N, “H-Gemcitabine: A New Gemcitabine Prodrug for Treating Cancer”, Bioconjug. Chem. 2013, 16;24(1):4-8.
  7. Acharya AP, Murthy N, “Synthetic vaccines: Immunity without harm” Nature Materials, 2011, 10(3):166-168.

Research Assistant, University of Florida, Gainesville (2005–2010)

  1. Acharya AP, Carstens MR, Lewis JS, Dolgova N, Xia CQ, Clare-Salzler MJ, Keselowsky BG “A cell-based microarray to investigate combinatorial effects of microparticle-encapsulated adjuvants on dendritic cell activation”, Journal of Materials Chemistry B, 2015.
  2. Carstens MR, Fisher RC, Acharya AP, Butterworth EA, Scott E, Huang EH, Keselowsky BG, “Drug-eluting microarrays to identify effective chemotherapeutic combinations targeting patient-derived cancer stem cells”, PNAS, 2015 Jul 14;112(28):8732-7.
  3. Han C, Choe SW, Kim YH, Acharya AP, Keselowsky BG, Sorg BS, Lee YJ, Oh SP, “VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2.” Angiogenesis. 2014 Oct;17(4):823-30.
  4. Lewis JS, Dolgova NV, Chancellor TJ, Acharya AP, Karpiak JV, Lele TP, Keselowsky BG, “The effect of cyclic mechanical strain on activation of dendritic cells cultured on adhesive substrates”, Biomaterials 2013, 34 (36), 9063-9070.
  5. Acharya AP, Lewis JS, Keselowsky BG. “Combinatorial Co-Encapsulation of Hydrophobic Molecules in Poly(lactide-co-glycolide) Microparticles” Biomaterials. 2013, 34(13):3422-30
  6. Berglund IS, Brar HS, Dolgova N, Acharya AP, Keselowsky BG, Sarntinoranont M, Manuel MV “Synthesis and characterization of Mg-Ca-Sr alloys for biodegradable orthopedic implant applications”, J Biomed Mater Res B Appl Biomater. 2012, 100(6):1524-34.
  7. Xu Y, Zhang C, Wang R, Barish P, Vernon M, Chen L, Govindarajan SS, Acharya AP, Li S, Boykin E, O’Donnell JM, Ogle W. “Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway” Neuroscience. 2011;182:71-81.
  8. Xu Y, Li S, Barish P, Zhang C, Vernon M, Boykin E, Acharya AP, Shyamala S, Pan J, Ogle W. “Curcumin modulation of neuroplasticity against corticosterone toxicity and the role of the 5-HT dependent molecular pathway in rat cortical neurons” J Neurochem. 2011;118(5):784-95.
  9. Acharya AP, Dolgova NV, Clare-Salzler MJ, Keselowsky BG. “Adhesive Substrates Modulates Activation and Stimulatory Capacity of Non-Obese Diabetic Mouse-Derived Dendritic Cells” Acta Biomaterialia 2010, 7(1):180-92.
  10. Acharya AP, Dolgova NV, Xia CQ, Clare-Salzler MJ, Becker M, Moore N, Gallant N, Keselowsky BG “Integrin-Mediated Peptide Adhesion Based Controlled Activation of Dendritic Cells” Biomaterials 2010, 31(29):7444-54.
  11. Choe SW, Acharya AP, Keselowsky BG, Sorg BS. “Intravital microscopy imaging of macrophage and tissue response to immunogenic particles” Acta Biomaterialia 2010, 6(9):3491-8.
  12. Choe SW, Acharya AP, Keselowsky BG, Sorg BS (2009). “Spectral and fluorescence imaging of immune system and tissue response to an immunogenic agent” Proceedings of SPIE, 7313: article 731305, 1-10 - Refereed Conference Proceedings.
  13. Acharya AP, Clare-Salzler MJ, Keselowsky BG. “A High-Throughput Microparticle Microarray Platform for Dendritic Cell-Targeting Vaccines” Biomaterials 2009, 30: 4168-77.
  14. Acharya AP, Dolgova NV, Clare-Salzler MJ, Keselowsky BG. “Adhesive Substrate Modulation of Adaptive Immune Responses” Biomaterials 2008, 29: 4736-4750.

Book Chapters

  1. "Biomaterials Science" - 4th edition, Chapter 2.2.3 Innate and Adaptive Immunity: The Immune Response to Foreign Materials; Benjamin G. Keselowsky, Abhinav P. Acharya and Jamal S. Lewis. Page 747.
  2. “Handbook of Biomaterials Biocompatibility” – Chapter 4 Dendritic Cell Responses to Biomaterials, Sahil Inamdar and Abhinav P. Acharya*. Page 53.

Patents

  • Patent# WO2014165566A1 – “Hydrophilic particle compositions, processes of production, and uses in dietary management and digestive disorders”, Emory University, Georgia Tech Research Corporation
  • Patent# WO2017004071A1 – “Stapled Acid-sensitive endosome disrupting alginates”, University of Pittsburgh, PA.
  • Patent# WO2017176899A1 – “Assay for detection of bladder or prostate cancer”, University of Pittsburgh, PA.
  • Patent# WO2019104038A1 – “Compositions and methods for administering a yap1/wwrt1 inhibiting composition and a gls1 inhibiting composition”, University of Pittsburgh, PA.
  • Patent# WO2019168990A1 – “Probiotics and probiotic compositions for regulating body weight”, University of Pittsburgh, PA.
  • PCT/US21/045183 “CAR therapies for treatment” – Abhinav Acharya, Mamta Wankhede, Under option – ImmunoMetabolix, LLC
  • PCT/US20/50305 “Metabolic reprogramming of immune for Autoimmune disorders Prevention/Reversal” - Abhinav Acharya, Joslyn Mangal, Under option – ImmunoMetabolix, LLC
  • PCT/US20/59610 “Central carbon metabolite based polymers for tissue regeneration” - Abhinav Acharya, Kaushal Rege, Under option – ImmunoMetabolix, LLC
  • PCT/US21/12691 “Central carbon metabolite based polymers for Immunotherapy” – Abhinav Acharya, Sahil Inamdar, Under option – ImmunoMetabolix, LLC
  • PCT/US20/33144 “Metabolite delivery for modulating metabolic pathways of cells” – Abhinav Acharya, Under option – ImmunoMetabolix, LLC
  • PCT/US63/478587 “Metabolite-Based Particles and Compositions Thereof For Preventing and Treating Neurological Diseases and Disorders” – Abhinav Acharya, Sarah Stabenfeldt, Under option – ImmunoMetabolix, LLC

Startup Companies from Acharya Lab